Role of molecular chaperon in gastric mucosal injury and restoration

最近的许多研究表明热休克蛋白（HSPs）对细胞在应激条件下存活的重要性。已知一些热休克蛋白通过其作为“分子伴侣”的功能参与对环境应激的细胞保护。我们已经报道了一种72 kDa的热休克蛋白，热休克蛋白72（HSP 72，stress-inducible HSP 70）在体内胃和结肠粘膜中起重要作用，本研究证明：1）锌衍生物诱导胃粘膜热休克蛋白72表达时，2）基因转染HSP 72过表达可明显增强细胞对乙醇损伤的保护能力，结果提示，HSP 72的表达不仅具有细胞保护作用，而且可能作为HSP 72的分子伴侣参与胃粘膜损伤修复。

Many recent studies have indicated the importance of heat shock (proteins (HSPs) for survival of cells under stress conditions. Some HSPs are known to be involved in cytoprotection against environmental stresses mediated by their function as a "molecular chaperon". We have reported that a 72-kDa heat shock protein (HSP72, stress-inducible HSP7O) plays essential role in the gastric and colonic mucosa in vivo.In the present study demonstrated that1)When gastric mucosal HSP72 is induced by zinc derivatives, protective ability and wound restoration are enhanced in vitro and in vivo.2)Over-expression of HSP72 by gene-transfection clearly enhanced cytoprotective ability against ethanol-induced cell damage and wound restoration in cultured gastric mucosal cells.Our results suggested that expression of HSP72 could play important roles not only in cytoprotection but also in mucosal wound restoration mediated by the function as a molecular chaperon of HSP72.