Normal database of cerebral blood flow and cerebral oxygen metabolism measured with PET and O-15 labeled gas.

用正电子发射断层扫描(PET)测量脑血流量、脑血容量(CBV)、脑氧摄取率(OEF)和CMRO_2。分别用氧标记二氧化碳(C^lt；15&gt；O_2)或氧标记水(8H_2；15&gt；O)、氧标记一氧化碳(C^&lt；15&gt；O)或氧标记氧(^&lt；15&gt；O；O2)对脑血管疾病的诊断和治疗计划有一定的参考价值。理论上，测量值取决于不同PET中心之间的不同因素。对来自11个PET中心的70名健康志愿者的PET数据进行分析。对于C^lt；15&gt；O_2，7个中心用稳态法，对8个中心用非稳态法。水的分配系数随中心的不同而在0.8~1.0之间变化。大脑皮层的总体平均值±SD为：CBF=44.4±6.5毫升/100毫升/分；CBV=3.8±0.7毫升/100毫升；OEF=0.44±0.06；CMRO_2=3.3±0.5毫升/100毫升/分；变异较小，提示建立正常的气体库是可行的。使用SPM99将每个受试者的CBF图像进一步空间归一化到标准Talairach坐标系中，并对其他三个参数图像进行相同的变换。该程序在标准坐标系中创建了每个参数的平均正常图像，这可能会以图像格式提供每个大脑区域的正常值。

Measurement of CBF, cerebral blood volume (CBV), cerebral oxygen extraction fraction (OEF), and CMRO_2 by positron emission tomography (PET) with ^<15>O-labeled carbon dioxide (C^<15>O_2) or ^<15>O-labeled water 8H_2^<15>O), ^15O-labeled carbon monoxide (C^<15>O), or ^<15>O-labeled oxygen (^<15>O_2) is useful for diagnosis and treatment planning in cases of cerebrovascular disease. The measured values theoretically depend on factors that differ between PET centers. PET data of 70 healthy volunteers from 11 PET centers were analyzed. Steady-state method was used in 7 centers for C^<15>O_2 and in 8 centers for ^<15>O_2. Non-steady-state method was used in the other centers. The partition coefficient of water varied from 0.8 to 1.0 depending on the centers. Overall mean ± SD values for cerebral cortical regions were : CBF = 44.4 ± 6.5 mL/100 mL/min ; CBV = 3.8 ± 0.7 mL/100 mL ; OEF = 0.44 ± 0.06 ; CMRO_2 = 3.3 ± 0.5 mL/100 mL/min ; the variations being acceptable small, suggesting the practicability of building a normal database for ^<15>O-labeled gas sturdy. The CBF image of each subject was further spatially normalized into the standard Talairach coordinates system using SPM99, and the other three parametric images were transformed with the same transformation. This procedure created the average normal images of each parameter in the standard coordinates system, which may provide normal values for each brain region in the image format.