The Function of Th-1 and Th-2 cytokine on herpetic stromal keratitis

实验性疱疹性角膜炎受角膜Th-1和Th-2平衡的影响。角膜炎早期以Th-1细胞因子为主，晚期以Th-2细胞因子为主。IL-18是潜在的IFN-γ产生因子和炎症调节剂。我们对角膜和疱疹性角膜炎的作用感兴趣。B6小鼠（Th-1优势小鼠）角膜炎症较重。Balb/c小鼠（Th-2显性）角膜损伤不严重，但发生脑炎死亡。测定B6小鼠和Balb/c小鼠疱疹性角膜炎角膜组织中IL-4、IL-10和IL-12的水平。B6小鼠和Balb/c小鼠在疱疹性角膜炎的早期和晚期血清中所有细胞因子的变化模式相同，因此我们认为Th-1/Th-2平衡没有明显变化。

Experimental herpetic keratitis is effected by Th-1 and Th-2 balance in cornea. In early stage of keratitis, Th-1 cytokine is dominant, in later Th-2 is dominant.IL-18 is potential IFN-γ producing factor and modulator of inflammation. We are interested in the function on cornea and herpetic keratitis.B6 mouse(Th-1 dominant mouse) is heavier inflammation on the cornea. Balb/c mouse(Th-2 dominant) is not serious on the cornea but become encephalitis and die. IL-4,IL-10 and IL-12 is measured in cornea on herpetic keratitis both B6 mouse and Balb/c mouse.All cytokine in serum is same pattern both B6 mouse and Balb/c mouse on early and later stage of herpetic keratitis, so we concluded no significant chane Th-1/Th-2 balance.