Evaluation of Autogenous Iliac Bone Grafting for Alveolar Cleft of Cleft Lip and Palate Patients-Use of Platelet Rich Plasma(PRP)-

对18例(18条)唇腭裂患者采用富含血小板血浆(PRP)行牙槽裂髂骨移植(PRP组)，并与17例(17条唇腭裂未行PRP组)患者(非PRP组)进行比较。术后1周、1个月、1个月、1个月、1个月、1个月、1个月、1个月、1个月、6个月分别拍摄牙槽裂植骨片，测量牙槽裂骨桥上、下缘水平。将厚度为0~16 mm的铝楔固定在牙片支架上，以铝当量(Al-Eq)值测量牙科X线片上的骨密度。术后6个月，骨桥上缘水平<1.0时手术效果良好，下缘水平>3.0时为失败，术后6个月…评分为失败更多的是两组人。结果如下：1.术前血浆平均血小板数为27.7×104/μL，平均血小板数为86.8×104/μL，浓缩率为319.9%。PRP组术后3个月Al-Eq迅速下降，术后6个月略有升高。非PRP组术后6个月Al-EQ逐渐降低。术后1周~3个月，PRP组和非PRP组的骨桥下缘略有缩小，但差异无统计学意义。两组术后1个月骨桥上缘均迅速吸收，此后基本保持不变。术后6个月PRP组9例中7例疗效良好(77.8%)，非PRP组17例中9例效果良好(52.9%)。4.术后1周~6个月，PRP组和非PRP组骨桥宽度改变率分别为77.2%和71.7%，表明PRP组的骨吸收略低于非PRP组，提示PRP通过作用于自体髂骨促进骨再生，取得了良好的植骨效果。较少

The postoperative changes in the grafting bone were evaluated in 18 patients with cleft lip and palate (18 clefts) who had undergone iliac bone grafting in the alveolar cleft using platelet rich plasma(PRP)(PRP group), and compared to those in 17 patients with cleft lip and palate (17 clefts) who had undergone grafting without PRP (non-PRP group).Dental X-ray with an aluminum wedge was taken in the grafted bone in the alveolar cleft, 1 week, and 1,3,and 6 months postoperatively, and the levels of the upper and lower margins of the bone bridge in the alveolar cleft was measured. The bone density on the dental X-ray film was also measured on an aluminum-equivalence(Al-Eq) value based on aluminum wedge with a thickness of 0 to 16 mm was mounted on the film holder.The surgical outcome was regarded as good when the level of the upper margin of the bone bridge was 1.0 or less and that of the lower margin was 3.0 or more 6 months postoperatively and as failure otherwise, and was evaluated on … More both groups. The results were as follows :1.Preoperatively, the mean number of platelets in the plasma was 27.7×10^4/μl, and that in the PRP was 86.8×10^4/μl, showing a concentration rate of 319.9%. It was confirmed that the number of platelets in the PRP were increased.2.The Al-Eq rapidly decreased up to 3 months postoperatively in the PRP group, and slightly increased 6 months postoperatively. In the non-PRP group, the Al-Eq gradually decreased up to 6 months postoperatively. Bone regeneration was slightly more rapid in the PRP group than in the non-PRP group.3.The lower margin of the bone bridge was slightly decreased from 1 week to 3 months postoperatively in the PRP and non-PRP groups, but the differences were not significant. The upper margin of the bone bridge was rapidly absorbed up to 1 month postoperatively in both groups, and then remained almost unchanged. Good outcomes 6 months postoperatively were observed in 7 of the 9 patients in the PRP group(77.8%), and in 9 of the 17 patients in the non-PRP group(52.9%).4.The rate of change in the bone bridge width between 1 week and 6 months postoperatively was 77.2% in the PRP group and 71.7% in the non-PRP group, indicating that bone absorption was slightly lower in the former than in the latter.These findings suggested that PRP enhanced bone regeneration by acting on the autogenous iliac bone, resulting in good outcomes of iliac bone grafting. Less