Cooperative Effects of Isoflavones and Exercise on Bone and Lipid Metabolism in Postmenopausal Japanese Women.

异黄酮和运动对雌激素缺乏动物骨和脂质代谢的累加效应已经被证实。在这项研究中，我们确定了异黄酮摄入、步行运动及其相互作用对绝经后日本妇女1年骨、脂肪量和脂质代谢的影响。方法：将136名绝经后妇女随机分为4组：(1)安慰剂组，(2)安慰剂组步行（45分钟/天，3天/周），(3)异黄酮摄入组（异黄酮缀合物75 mg /天），(4)异黄酮加步行组。评估骨密度（BMD）、脂肪量、血脂、血清和尿异黄酮浓度。结果：在12个月时，异黄酮对降低躯干脂肪量有显著的主要作用。在3个月、6个月和12个月时观察到步行对全身和躯干脂肪量的减少有显著的主要作用，在6个月和12个月时观察到腿部和手臂脂肪量的减少。在步行和联合干预后12个月，血清高密度脂蛋白胆固醇浓度显著升高。12个月后，异黄酮对骨密度的主要影响仅在沃德三角区可见。步行在很大程度上防止了整个髋关节和沃德三角区的骨质流失。联合干预对骨密度和脂肪量的影响大于单独干预。在研究期间记录的任何测量中，没有观察到异黄酮和步行之间的显著相互作用。结论：我们的研究表明，联合干预75 mg/天的异黄酮摄入和3次/周的步行运动，持续1年，对全髋关节和沃德三角区的骨密度的影响比单独干预更大。与西方妇女相比，对绝经后日本妇女进行异黄酮干预对骨密度的影响不大。为了确定异黄酮加步行联合干预绝经后妇女的临床意义，有必要在更长的治疗时间内进行进一步的研究，包括评估各区域的骨密度。少

Introduction : The additive effects of isoflavones and exercise on bone and lipid metabolism have been demonstrated in estrogen-deficient animals. In this study, we determined the effects of isoflavone intake, walking exercise, and their interaction on bone, fat mass, and lipid metabolism over 1 year in postmenopausal Japanese women.Methods : A total of 136 postmenopausal women at <5 years after the onset of menopause were randomly assigned to four groups : (1) placebo, (2) walking (45 min/day, 3 days/week) with placebo, (3) isoflavone intake (75 mg of isoflavone conjugates/day), and (4) combination of isoflavone plus walking. Bone mineral density (BMD), fat mass, serum lipid, and serum and urinary isoflavone concentrations were assessed.Results : A significant main effect of isoflavone on the reduction in trunk fat mass was obtained at 12 months. Significant main effects of walking on the reduction in fat mass in the whole body and the trunk were observed at 3, 6, and 12 months and th … More at in the legs and arms at 6 and 12 months. Serum HDL cholesterol concentration significantly increased by 12 months following the walking and the combined intervention. After 12 months, a significant main effect of isoflavone on BMD was observed only at Ward's triangle. Walking prevented bone loss at the total hip and the Ward's triangle to significant degrees. The effect of the combined intervention on BMD and fat mass was greater than that of either alone. No significant interaction was observed between isoflavone and walking in any measurements recorded during the study.Conclusion : Our study suggest that combined intervention of 75 mg/day of isoflavone intake and walking exercise 3 times/week for 1 year showed a trend for a greater effect on BMD at total hip and Ward's triangle regions than either alone. Intervention with isoflavone in postmenopausal Japanese women showed a modest effect on BMD when compared with those in the Westerners. Further studies over longer treatment duration that include assessment of BMD at various regions are necessary to ascertain the clinical significance of the combined intervention of isoflavone plus walking in postmenopausal women. Less