The development of new radiofrequency device and its clinical application

盐水增强射频消融是一种获得更大凝血面积的新方法，在射频消融过程中，通过电极侧孔将生理盐水一滴一滴地注入肿瘤组织。我们使用Elektrotom 106 HITT （Berchtold）对离体肝实质进行了盐增强射频消融，该技术在欧洲可市售，但意外的是，不希望的大面积凝固。因此，我们认为Elektrotom 106 HITT在患者身上的临床应用可能不安全。我们使用广泛使用的Cool-tip电极进行射频消融，用2到4根PEIT针在Cool-tip电极周围放置1-2cm处注射5毫升生理盐水，并在电极周围获得大的凝血区域。然后对7例2.5-5.2cm肝细胞癌（HCC）患者（年龄60-76岁，男/女；5/2）进行了盐增强射频技术治疗。临床效果好；治疗效果完全，无局部肿瘤进展。在未来，我们希望使用这种盐水增强技术治疗大于5cm的HCC结节。

Saline-enhanced RF ablation is a new procedure to obtain larger coagulation area, injecting physiologic saline drop by drop through the side holes of the electrode into tumor tissues during the RF ablation. We performed saline-enhanced RF ablation for ex-vivo liver parenchyma with Elektrotom 106 HITT (Berchtold) which is commercially available in Europe, but unexpected, undesirable large area was coagulated. So, we believe the clinical application of the Elektrotom 106 HITT to patients might be not safe. We performed RF ablation with a widely-used Cool-tip electrode, injecting 5-ml saline with two to four PEIT needles placing 1-2cm around the Cool-tip electrode, and obtained large coagulation areas around the electrode. Then, seven cases (age; 60-76 years, man/woman; 5/2) with 2.5-5.2cm hepatocellular carcinoma (HCC) was treated with this saline-enhanced RF technique. Good clinical results; complete treatment effects and no local tumor progression were obtained. In the future, we would like to treat a HCC nodule larger than 5cm, using this saline-enhanced technique.