Regulated adhesion and neo-vascularization with mesothelium in the prefabricated flap

目前，在组织重建领域已经发展了“预构皮瓣”。在这种方法中，在皮瓣抬高之前，将血管化组织作为“血管载体”植入。几个月后，新创建的皮瓣可以通过血管载体的血液供应来提升。这种方法是基于诱导的血管载体和覆盖组织之间的新血管形成。然而，新生血管和血管载体与周围组织的粘附可能固有地导致皮瓣抬高的困难。我们以空肠浆肌瓣为血管载体，发展了一种预构皮瓣。空肠浆肌瓣含有用于新生血管形成的粘膜下层，但也具有可防止粘连和新生血管形成的浆膜。我们证实了以空肠浆肌皮瓣为基础的预构皮瓣作为血管载体的实用性。

Currently, the "prefabricated flap" has been developed in the field of tissue reconstruction. In this method, a vascularized tissue is implanted as a "vascular carrier" prior to the flap elevation. A few months later, a newly created flap can be elevated with the blood supply via the vascular carrier. This method is based on the neo-vascularization between the induced vascular carrier and the overlying tissue. However, neovascularization and adhesion of the vascular carrier to the surrounding tissue may inherently result in difficulty of the flap elevation. We developed a prefabricated flap using jejunal seromuscular flap as a vascular carrier. The jejunal seromuscular flap contains a submucosal layer for the neovascularization, but also having a serosa which can prevent adhesion and neovascularization. We confirmed the utility of the prefabricated flap based on the jejunal seromuscular flap as a vascular carrier.