Synthesis of Mono-Functional Olefin Metathesis Polymers

本研究计划的目的是为制备定义明确的单端功能复分解聚合物提供新的合成途径。目前，开环复分解聚合（ROMP）允许从大量功能单体合成定义明确的聚合物。然而，精确地引入一个定义良好的功能端基是很难实现的。尽管对于非专业人士来说，这是一种非常有吸引力的聚合技术，但这一缺点限制了它在跨学科领域的应用。我们最近展示了一种新的合成方法，使用一种易于遵循的牺牲嵌段共聚物技术来克服这一限制。初步工作仅限于羟基官能团。在这里，我们提出了这种方法的发展，以便能够引入各种官能团，如胺、硫醇或羧酸，以明确定义的功能聚合物的末端。沿着聚合物链携带一种官能团而在链端提供不同官能团的聚合物很难制备，特别适用于合成生物大分子偶联物、嵌段共聚物、表面活性剂、胶体以及表面和纳米颗粒的功能化。

The aim of this research proposal is to provide new synthetic routes for the preparation of well-defined mono-end-functional metathesis polymers. Currently, the ring opening metathesis polymerisation (ROMP) allows the synthesis of well-defined polymers from a large pool of functional monomers. The introduction of exactly one well-defined functional end-group, however, is difficult to achieve. While otherwise a very attractive polymerisation technique even for the non-specialist, this drawback has limited its application across interdisciplinary borders. We recently demonstrated a new synthetic approach to overcome this limitation using an easy to follow sacrificial block-copolymer technique. The preliminary work was limited to hydroxy functional groups. Here we propose the development of this approach in order to be able to introduce a variety of functional groups such as amines, thiols or carboxylic acids to the end of a well-define functional polymer. Polymers carrying one type of functional group along the polymer chain while providing a different functionality at the chain end are otherwise difficult to prepare and particularly useful for the synthesis of biomacromolecule conjugates, block copolymers, surfactants, colloids and the functionalisation of surfaces and nano-particles.