Meeting the Challenges of Chronic Age-Related Diseases in Rural Areas

格雷夫斯瓦尔德大学医学院（UMG）将实施一项最先进的临床医生科学家计划（CSP），这是加强其作为面向未来农村地区患者护理需求的转化研究中心的重要组成部分。来自心血管医学、神经病学和肿瘤学临床科室的合作伙伴将与医学生物化学研究所、生物信息学研究所和社区医学研究所联合起来，在研究和患者护理方面解决与年龄相关的常见疾病。我们将利用在蛋白质平衡、数据挖掘方法、临床试验和卫生服务研究方面广泛开展的工作，为年轻的临床科学家（CS）研究员提供具有国际竞争力的研究培训和临床技能。在他们的科学轮换中，CS研究员将获得应用尖端科学实验室技术和临床试验方法的知识，以及现代数据挖掘和机器学习方法，以揭示心肌病，肌肉萎缩，虚弱，痴呆，谵妄和慢性髓系肿瘤的潜在机制，并为这些疾病开发新的治疗方法。在他们的临床工作中，CS研究员将进入一个明确的轮岗计划，该计划将培训他们为所研究的人群提供跨学科的患者护理。根据“UMG 2026”战略议程的定义，社区战略计划将被纳入UMG的总体研究议程，该议程明确了四个主要研究平台（社区医学、分子医学、个体化医学和数字卫生）的重点，所有这些都将纳入社区战略计划，并将促进转化研究和向农村社区推广作为UMG概况的构成要素。总而言之，所有CSP项目都将在临床和患者相关方面对研究员进行资格和培训，并使他们能够走上具有国际竞争力的科学道路。此外，通过确保积极进取的年轻临床科学家的定期队列，CSP将持续推动UMG的努力，以确定慢性年龄相关疾病的分子和临床特征，利用机器学习利用临床信息系统的数字数据进行数据驱动的健康研究，并开发数字诊断和治疗方法，以供社区使用。这里概述的CSP将持续锚定在UMG内，包括CS研究员职位，高级CS研究员职位，以及广泛的相关研讨会和讲习班计划。

The University Medicine Greifswald (UMG) will implement a state of the art Clinician Scientist program (CSP) that forms an essential building block for strengthening its profile as a center for translational research oriented towards the needs of patient care in rural areas in the future. Partners from the clinical departments of Cardiovascular Medicine, Neurology, and Oncology will join forces with the Institutes of Medical Biochemistry, Bioinformatics, and Community Medicine to address common, age-related diseases in both research and patient care. We will draw on extensive ongoing work on proteostasis, data mining methods, clinical trials and health services research, to offer internationally competitive research training and clinical skills to young Clinician Scientist (CS) fellows. In their scientific rotation, the CS fellows will acquire knowledge in applying cutting-edge scientific laboratory techniques and clinical trial methodology, as well as modern data mining and machine learning approaches to unravel mechanisms underlying cardiomyopathies, muscle wasting, frailty, dementia, delirium, and chronic myeloid neoplasms, and to develop novel therapeutic approaches for these conditions. In their clinical work, the CS fellows will enter a well-defined rotation scheme that will train them in interdisciplinary patient care for populations under study. The CSP will be embedded into the overall research agenda of the UMG, as defined in the strategic agenda “UMG 2026”, which specifies a focus on four main Research Platforms (Community Medicine, Molecular Medicine, Individualized Medicine and Digital Health), all of which will be integrated in the CSP, and the promotion of translational research and outreach into the rural community as constitutive elements for the profile of the UMG. In sum, all CSP projects will qualify and train the fellows in clinical and patient-related aspects, and empower them for an internationally competitive scientific track. In addition, by ensuring regular cohorts of highly motivated young clinician scientists, the CSP will sustainably boost the UMG’s efforts to identify molecular and clinical signatures of chronic age-related diseases, to use machine learning to harness digital data from the clinical information system for data-driven health research, and to develop digital diagnostic and therapeutic approaches for use in the community. The CSP outlined here will be sustainably anchored within the UMG, including CS fellow positions, advanced CS fellow positions, and the extensive accompanying seminar and workshop program.