GRK 2873: Tools and Drugs of the Future - Innovative Methods and New Modalities in Medicinal Chemistry

药物化学是一个高度交叉的研究领域，专注于生物活性工具化合物和药物的发现、表征和开发。近年来，药物化学和药物研究的目标格局以及药物分子的类型(“药物形态”)和所采用的方法发生了重大变化。因此，在计划中的RTG中，我们打算教育和培训下一代药物化学家，他们将为应对未来的挑战做好充分准备。将采用不同的战略来发现针对新型靶标的工具和药物。该研究计划集中在四个密切相关的核心主题上：(I)靶向蛋白质降解物(PROTAC)，(Ii)大环药物，(Iii)作为工具和药物的生物聚合物，以及(Iv)药物结合物。这些研究项目得到了共同使用的技术平台的支持：专有的Pharma-Zentum Bonn化合物库、适体研发中心卡、结构生物学平台和药物化学先进仪器平台。这项RTG提案是由来自两个学院(数学和自然科学学院和医学院)的五个不同研究所的主要研究人员起草的，他们之前有过成功合作的历史。不同的私人投资者群体包括有经验的和年轻的有抱负的研究人员。研究人员的广泛科学背景及其相互联系将使我们能够在涵盖广泛的新模式方面获得相当大的协同效应，所有这些新模式都有不同于经典药物的共同点：它们的性质超出了利平斯基的5法则(Ro5)，导致了必须解决的类似问题。RTG将允许密切互动，以解决由此产生的科学问题。波恩大学及其周围环境，包括行业合作伙伴，不仅为药物化学研究提供了理想的环境，也为转化药物的开发提供了理想的环境。我们计划对博士生进行为期3到4年的资格认证。它包括高级药物化学系列讲座、讲习班、中央博士座谈会、国际系列讲座和国际职业发展计划，其中包括软技能、科学哲学和科学伦理课程。我们将与我们享有特权的国际合作机构，哥本哈根大学(丹麦)、邓迪大学(苏格兰)和东北大学(日本)密切合作，我们已经与这些大学就博士生实验室交流计划达成一致。创新药物化学重点领域，培养和造就新一代药物化学与相关学科对接的药物化学家和青年科学家。此外，这些研究项目将有助于药物研究和开发，造福患者。

Medicinal Chemistry is a highly interdisciplinary field of research that focuses on the discovery, characterization and development of bioactive tool compounds and drugs. In recent years, the target landscape as well as the types of drug molecules (“drug modalities”) and the methods employed in Medicinal Chemistry and drug research have significantly changed. In the planned RTG we therefore intend to educate and train a future generation of medicinal chemists that will be well prepared to master future challenges. Different strategies will be employed to discover tools and drugs for novel types of targets. The research program focuses on four core themes that are closely interconnected: (I) targeted protein degraders (PROTACs), (II) macrocyclic drugs, (III) biopolymers as tools and drugs, and (IV) drug conjugates. The research projects are supported by jointly used technology platforms: the proprietary Pharma-Zentrum Bonn compound library, the Center of Aptamer Research and Development CARD, a structural biology platform, and a platform of advanced instruments in medicinal chemistry. This RTG proposal has been composed by leading researchers from five different institutes of two faculties (Faculty of Mathematics and Natural Sciences and Faculty of Medicine), who have a history of previous successful collaborations. The diverse group of PIs comprises experienced as well as young aspiring researchers. The broad scientific backgrounds of the researchers and their interconnections will allow us to gain considerable synergies in covering a wide variety of new modalities, all of which have in common that they differ from classical drugs: their properties are beyond Lipinski’s rule of 5 (Ro5) resulting in similar problems that have to be solved. The RTG will allow close interactions to tackle the resulting scientific questions. The University of Bonn and its surroundings, including industry partners, provide an ideal environment not only for research in Medicinal Chemistry, but also for translational drug development. We have planned a 3- to 4-year qualification program for the doctoral researchers. It comprises a lecture series in advanced medicinal chemistry, workshops, a central doctoral colloquium, an international lecture series and an international career development program comprising courses in soft skills, science philosophy and ethics in science. We will closely collaborate with our privileged international partner institutions, the Universities of Copenhagen (Denmark), Dundee (Scotland) and Tohoku (Japan) with which we have agreed on a lab exchange program for the doctoral students. We will innovate in key areas of medicinal chemistry and educate and train a new generation of medicinal chemists and young scientists at the interface between medicinal chemistry and interconnected disciplines. Moreover, the research projects will contribute to drug research and development for the benefit of patients.