Improving and manipulating the immune adjuvant properties of recombinant fowlpox vectors

不平衡的免疫反应可能导致或加重常见和重要的疾病，如感染、过敏、癌症和自身免疫。白细胞介素-4 （IL-4）是唯一的免疫活性产物或细胞因子，可以安全地将异常免疫反应扭曲为愈合型反应。禽痘病毒（FPV）提供安全有效的人类疫苗。工程FPV制造相关抗原和细胞因子是一项专有技术。我们将与我们的商业合作伙伴一起使用实验小鼠，测试FPV制造模型抗原和IL-4启动和/或维持有益的2型反应的概念。一个成功的结果将指导临床基于fpv的疫苗开发，用于治疗重要的人类和兽医疾病。

Unbalanced immune responses may cause or worsen common and important diseases such as infections, allergies, cancers and autoimmunity. Interleukin-4 (IL-4) is the only immune active product or cytokine that safely skews an aberrant immune response to a healing type of response. Fowlpox viruses (FPV) provide safe and effective human vaccines. Engineering FPV to make both a relevant antigen and a cytokine is proprietary technology. With our commercial partner and using experimental mice, we will test the concept that FPV making a model antigen and IL-4 initiate and/or maintain beneficial Type 2 responses. A successful outcome will guide clinical FPV-based vaccine development for the treatment of important human and veterinary diseases.