Epigenetic clocks, blood-based biomarkers and functional parameters for the estimation of biological age (C06)

有一个未满足的需要，找到一个适当的模型的生物年龄。在这个项目中，我们使用特征良好的ActiFE队列，基于血液生物标志物、相关临床和功能参数以及靶向表观遗传时钟，开发了一个生物学年龄模型。该分析还将整合基于DNA甲基化分析的新概念。在一个翻译的方法，我们将检查表观遗传时钟也在小鼠。我们的联合研究将调查生物年龄，脆弱性和表观遗传衰老之间的界面，为生物年龄评估提供一个新的结构。

There is an unmet need to find an adequate model for biological age. In this project, we use the well characterized ActiFE cohort to develop a model for biological age based on blood-based biomarkers, relevant clinical and functional parameters, and targeted epigenetic clocks. The analysis will also integrate new concepts based on DNA methylation analysis. In a translational approach we will examine epigenetic clocks also in mice. Our joint research will investigate the interface between biological age, frailty, and epigenetic aging to provide a new construct for biological age assessment.