Remodeling of tricellular junctions controls paracellular transport (B11*)

在卵生动物的卵子发生过程中，卵泡上皮中的三细胞连接瞬间开放，允许卵黄蛋白通过被卵母细胞摄取。我们将研究这个过程，称为通畅性，以果蝇为模型系统，了解三个细胞之间界面黏附复合体的动态重塑如何控制上皮的通透性。我们将研究内吞作用、肌球蛋白收缩特性和细胞体积的调节如何调节细胞顶点的瞬时开放。

During oogenesis in oviparous animals, tricellular junctions in the follicular epithelium open transiently to allow passage of yolk proteins for uptake by the oocyte. We will study this process, referred to as patency, using Drosophila as a model system to understand how the dynamic remodeling of adhesion complexes at the interface between three cells controls epithelial permeability. We will investigate how the regulation of endocytosis, actomyosin contractility and of cell volume mediate transient opening of cell vertices.