Investigation on high throughput chemical synthesis by utilizing micro chemical systems

本研究的目的是构建高通量合成微系统，包括合成效率评价和微系统设计指南的建立。研究方向为：(1)高通量合成微系统的构建；(2)堆垛式生产系统的开发；(3)微组合合成系统的开发；(4)利用微空间特性创建微反应场。首先，我们提取了微空间中化学反应的特征，并结合微单元操作（MUO）建立了我们独创的微芯片连续流化学处理（CFCP）方法。在此基础上，构建了微化学合成系统、堆式反应器系统和组合合成系统。我们还通过开发新颖的muo来扩大我们的方法。实现了微逆流萃取、液-液或气-液多相流稳定、细胞长期培养、微生物反应器基础技术等。进一步推导了反应器的尺寸为100 nm，并建立了微纳系统的连接。

Objective of this research was construction of high throughput synthesis microsystem, which included evaluation of synthesis efficiency and establishment of guidelines for the microsystem design. The following issues were investigated : (1)Construction of highthroughput synthesis microsystem, (2)Development of piled-up production system, (3)Development of micro combinatorial synthesis system, and (4)Creation of micro reaction field utilizing features of microspace. First of all, we extracted characteristics of chemical reactions in microspace and established our original methodology of continous flow chemical processing (CFCP) on microchip by combining micro unit operations (MUO). Then, we constructed micro chemical synthesis system, piled-up reactor system, and combinatorial synthesis system. We also widen our methodology by developing novel MUOs. For example, micro counter-current extraction, stabilization of liquid-liquid or gas-liquid multiphase flows, long-term cultivation of cells, and fundamental technologies for micro bio-reactor were realized. Furthermore, size of reactor was deduced to a 100-nm scale and connection of micro-and nano-systems was established.