Molecular therapeutics targeting drug-resistance mechanisms

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We studied molecular mechanisms of various types of drug resistance, such as apoptosis resistance, tumor microenvironment-associated drug resistance, PDK1-Akt-related cell survival signaling pathways, and telomere-mediated cell maintenance. We succeeded to identify new molecular targets and to discover compounds that inhibit such molecular targets. By evaluating the antitumor effect of such compounds, we accumulated fundamental information to develop new molecular-targeted therapy that controls drug resistance features of tumor cells.