Drug discovery research based on the molecular mechanisms of tumor growth and metastasis

本研究旨在阐明肿瘤生长和转移的分子机制，并利用微生物代谢产物和化学文库开发新的抗癌药物。我们通过对转移相关蛋白如RECK和肝素酶的分析发现了一些新的分子靶点，并建立了蛋白质组学分析系统，根据作用机制对化合物进行分类。此外，我们还开发了多种抗癌先导化合物，包括骨转移抑制剂（reveromycin A）、抗血管生成剂（环氧喹啉B）、破骨细胞生成抑制剂（methyl-gerfelin）和嘌呤没食子素（purpurogallin）。

The purpose of this study is to clarify the molecular mechanisms of tumor growth and metastasis, and to develop new anticancer agents using microbial metabolites and chemical library. We exhibited some new molecular targets through the analysis of metastasis-related proteins such as RECK and heparanase, and developed proteomic profiling system for classification of compounds according to the mechanism of action. In addition, we developed various anticancer lead compounds including reveromycin A (bone metastasis inhibitor9), epoxyquinol B (antiangiogenic agent), methyl-gerfelin (osteoclastogenesis inhibitor), and purpurogallin (inhibitor of PBD dependent binding).