In Vivo Imaging System for small animals

动物研究对于研究复杂的生物过程和疾病是必不可少的。申请者的研究项目适用于肿瘤生物学和治疗、炎症和免疫学、心血管和神经疾病的活体成像研究。该仪器应该能够对小动物进行多参数、高分辨率的发光和荧光分析，以便深入了解疾病的发展并测试新的治疗方法。要求的规格如下：1)多只小鼠并行的非侵入性2D荧光和生物发光成像；2)快速2D透照，在深层组织中实现高灵敏度的荧光断层成像；3)3D成像，精确评估肿瘤或炎症等疾病的空间分布；4)多参数研究，结合发光，分析不同细胞类型的复杂相互作用；6)根据国际标准的分析工具，以便更好地与已发表的研究进行比较；7)集成麻醉学设备，用于有效地进行实验

Animal studies are essential for investigating complex biological processes and diseases. The research projects of the applicants apply “in vivo live imaging” studies in tumor biology and therapy, inflammation and immunology, cardiovascular and neurological diseases. The instrument should enable multiparametric, high-resolution luminescence and fluorescence analyses in small animals in order to obtain insight into the development of diseases and test novel therapeutic approaches. The following specifications are required: 1) non-invasive 2D Fluorescence- and Bioluminescence imaging of several mice in parallel; 2) fast 2D Trans-Illumination for high sensitivity of fluorescence-tomography in deep-set tissues; 3) 3D imaging to exactly assess the spatial distribution of diseases such as tumors or inflammation; 4) multiparametric studies of several fluorescence markers together with luminescence to enable analyses of complex interactions of different cell types; 6) analyses tools according to international standard for a better comparison to published studies; 7) an integrated anesthesiology device for efficient conduction of the experiments