Total Control of Psycho-immune-endocrine system ; revealing stress specific cytokine cascade

在这项研究中，我们揭示了(1)客观化压力负荷的人类血清学标记，(2)通过白介素18、超氧化物和肿瘤坏死因子诱导细胞因子的途径，(3)涉及线粒体的细胞因子诱导途径，(4)与重大抑郁疾病严重程度相关的人类血清学标记，以及(5)预测应激后心理行为障碍的人类血清标记。我们已经在包括全体会议在内的几次学术会议上报告了这些结果。同时，我们开发的后应力型凹陷客观化技术已实际应用于参与东北地震救援行动的人员。

In this study, we have revealed (1) human serological marker to objectify what and how much stress is loaded, (2) a pathway for cytokine induction via interleukin(IL) 18, superoxide, and tumor-necrotizing-factor, (3) a pathway for cytokine induction involving mitochondria, (4) a human serological marker that associates with severity of major depressive disease, and (5) a human serological marker that predicts psycho-behavioral disorders after stress. We have reported these results in several academic meeting including plenary lectures. At the same time, our developed technique to objectify post-stress depression have been practically utilized for people participated to rescue operation of the Tohoku Earthquake.