A new tracer development for positron emission tomographic imaging with an isotope62Zn containing porphyrins

为了开发一种新的正电子发射断层成像（PET）示踪剂，我们新合成了一种含有62Zn的卟啉衍生物，该衍生物已被报道在肿瘤细胞中积累。我们研究了我们的锌卟啉对癌细胞移植小鼠肿瘤区域诊断的功效。这些示踪剂在肿瘤组织以及肝脏和脾脏中积累，这两个器官在血红素代谢中起重要作用。根据这些结果，建议62zn -卟啉是PET成像中肿瘤示踪剂的候选物之一。

To develop a new tracer for positron emission tomography imaging(PET), we newly synthesized 62Zn containing porphyrin derivatives which have been reported to be accumulated in neoplastic cells. We investigated the efficacy of our Zn-porphyrins for tumor-area diagnosis with cancer cell-transplanted mice. These tracers were accumulated in the tumor tissue, as well as the liver and the spleen: both organs play important role for heme metabolisms. According to these results, 62Zn-porphyrin is suggested to be one of candidates for a tumor tracer in PET imaging.