Analysis of phospholipid metabolic enzymes in thyroid tumors

磷脂酰肌醇是组成细胞膜的重要脂类之一，有8种。它们的丰度很少，但它们作为信号分子发挥作用，每个物种的生产或降解功能障碍会导致严重疾病，因此它们被广泛研究。在这项研究中，我们通过创建基因敲除小鼠来分析其酶的生理作用。我们发现这些酶在甲状腺肿瘤中起着重要作用。

Phosphatidylinositols are one of the important lipids composed of cell membranes, and there are eight species. Their abundance is very little, but they function as a signal molecule, and the dysfunction of the production or degradation of each species causes critical diseases, so they have been extensively researched. In this study, we analyzed the physiological roles by creating knockout mice for their enzymes. We found that the enzymes had an important role in thyroid tumors.