Gold-Catalyzed Late-Stage Diversification of Prenylated Pharmaceuticals and Biomolecules with Acetylene Gas

本研究项目的目的是以金(I)为催化剂，以高取代度的烯烃和乙炔为原料合成1，3-丁二烯。主要的焦点将放在该反应的立体选择性上，因为在生成的二烯产品中可能存在不同的双键几何结构。这种选择性是通过新型的、空间要求很高的金(I)络合物来实现的，这种络合物应该只允许形成单一的非对映异构体。通过这种反应，存在于许多不同天然产品和药物中的戊烯基残留物可以延伸到1，3-丁二烯。这一反应可能有助于药物的后期功能化，以寻找更有效的衍生物，并将进行研究。

The aim of the research project is the synthesis of 1,3-butadienes starting from highly substituted olefins and acetylene under gold(I) catalysis. The main focus will be on the stereoselectivity of this reaction, since different double bond geometries are possible in the resulting diene products. This selectivity is to be achieved by novel, sterically demanding gold(I) complexes, which should only allow the formation of a single diastereomer. By such a reaction, prenyl residues, which occur in many different natural products and pharmaceuticals, could be extended to 1,3-butadienes. This reaction could be useful for late-stage functionalization of pharmaceuticals in the search for more potent derivatives and will also be investigated.