Disease-overarching mechanisms of Treg-CNS interaction (B06)

Treg细胞侵入脑的确切调控和途径，与受损脑组织及其细胞相互作用伙伴的相互作用机制在很大程度上仍然是未知的。尽管中风和多发性硬化症之间的疾病病因学存在明显差异，但由于特定神经炎症通路的许多共性，比较这两种重要的神经系统疾病具有很大的潜力，可以揭示CNS损伤和恢复中Treg细胞依赖性作用的共同机制。两个Co-PI的实验室拥有互补的资源和知识，以确定神经炎症中的疾病特异性和可推广的Treg-CNS机制。

The exact regulation and routes of Treg cell invasion to the brain, the mechanisms of interaction with the injured brain tissue and its cellular interaction partners are still largely unknown. Due to many commonalities in specific neuroinflammatory pathways despite the obvious differences in disease etiology between stroke and multiple sclerosis, comparing these two important neurological diseases has great potential to uncover common mechanisms of Treg cell-dependent effects in CNS injury and recovery. The laboratories of the two Co-PIs have complementary resources and knowledge to identify both disease-specific and generalizable Treg-CNS mechanisms in neuroinflammation.