课题基金 / 基金详情

Paracrine secretion; its function, morphology and concept

Paracrine secretion; its function, morphology and concept
旁分泌分泌;
批准号:
60304042
负责人:
KANNO Tomio
金额:
$4.86万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Co-operative Research (A)
财政年份:
1985
资助国家:
日本
项目状态:
已结题
起止时间:
1985 至 1986

项目摘要

项目成果

KANNO Tomio的其他基金

相似基金

相关文献

中文摘要
翻译
电刺激脊髓背根诱导细胞色素<aa_3>、b和c+ <c_1>平行降低,并连续记录在牛蛙大脑半球表面。VIP使细胞色素减少无效。氧化还原效应也可能是旁分泌效应的一部分。(KANNO)采用多肽合成的溶液法合成了20多个3或4位取代甘氨酸的CCK8和CCK7类似物。其中琥珀化[D- <Trp^3>]- cck7和琥珀化[D- <Ala^3>]- cck7对麻醉大鼠胰腺外分泌的刺激程度与CCK8几乎相同。在小龙虾中枢神经系统的末梢神经节中发现了一种不产生尖刺的新型神经元,即非尖刺神经元。研究了这些神经元的突触特性,作为分析旁分泌细胞缓慢电位变化作用的模型。(HISADA)在另一个新生大鼠的脊髓-尾部分离制备中,辣椒素在尾巴上的应用引起了腰椎腹侧根的缓慢去极化反应。(OTSUKA)本研究结果表明NA通过<alpha_1>受体激活SON大细胞,而NA通过<alpha_2>受体抑制PVN细小细胞。制备了抗三磷酸肌苷(TPI)抗体,并应用于耳蜗毛细胞。结果表明,TPI明显存在于毛膜外表面。(YANAGISAWA17 < β > -ES)以剂量-反应方式快速抑制Med-AMG神经元的兴奋性。(OOMURA)独立于肾上腺素能调节的肽能调节在松果体功能中起重要作用。免疫细胞化学研究在豚鼠小肠中进行。(KOBAYASHI)用电镜和免疫组织化学相结合的方法研究了不同种类的神经元和副神经元及其链的结构和功能。(FUJITA)少
英文摘要
Electrical stimulation of the dorsal root of the spinal cord induced parallel reduction of the cytochromes, <aa_3> , b and c+ <c_1> , which are recorded continuously on the surface of the cerebral hemisphere of the bullfrog brain. VIP nullified the cytochrome reduction. The redox effect may also be a part of the paracrine effects. (KANNO)More than twenty analogs of CCK8 and CCK7 with a substituted glycine at position 3 or 4 were synthesized by the solution method for peptide synthesis. Among them, succinylated [D- <Trp^3> ]-CCK7 and succinylated [D- <Ala^3> ]-CCK7 were found to stimulate pancreatic exocrine secretion in anesthetized rats to almost same extent as did CCK8. (YANAIHARA)A novel type of neurons which do not generate spike, non-spiking neurons, were found in the terminal ganglion of the crayfish central nervous system. The synaptic properties of these neurons were studied as a model for the analysis of the role of the slow potential change in the paracrine cells. (HISADA)In … More an isolated spinal cord-tail preparation of the newborn rat, application of capsaicin to the tail evoked a slow depolarizing response of the lumbar ventral root. (OTSUKA)The present results suggest that NA excites SON magnocellular cells through the <alpha_1> receptor, while NA inhibits PVN parvocellular cells through the <alpha_2> receptor. (YAMASHITA)The antibody to triphosphoinositide (TPI) was made and applied to the cochlear hair cells. The result showed TPI clearly exists on the outer surface of the hair membrane. (YANAGISAWA17 <beta> -estradiol (17 <beta> -ES) rapidly inhibited the excitability of Med-AMG neurons with a dose-response manner. (OOMURA)Peptidergic regulation independent of adrenergic regulation plays an important role in the pineal function. (KANEKO)Immunocytochemical studies were performed in the guinea pig small intestine. (KOBAYASHI)Different kinds of neurons and paraneurons, as well as the structure and function of the chains formed of them were studied by combined electron-microscopic and immunohistochemical techniques. (FUJITA) Less
期刊论文(44)
专著(0)
科研奖励(0)
会议论文
奥屋茂: Journal of Physiology. (1987)
奥谷茂:生理学杂志(1987)。
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
鍋倉淳一: Science. 233. 226-228 (1986)
锅仓淳一:科学。233。226-228(1986)
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
加来浩平: Endocrinology. 117. 2371-2375 (1985)
加来晃平:内分泌学。117。2371-2375(1985)
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Shigeru Kobayashi: "Framework of the enteric nerve plexuses: an immunocytochemical study in the guinea pig jejunum using an antiserum to S-100 protein" Archivum histologicum japonicum. 49. 159-188 (1986)
Shigeru Kobayashi:“肠神经丛的框架:使用 S-100 蛋白抗血清对豚鼠空肠进行的免疫细胞化学研究”Archivum histologicum japonicum。
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
共 43 条
    Chromaffin cells as a neuron model
    • 批准号:
      07308074
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $1.98万
    • 财政年份:
      1995
    • 负责人:
      KANNO Tomio
    • 依托单位:
    Relation between redox state and secretory response to brain-gut peptides
    • 批准号:
      61440025
    • 项目类别:
      Grant-in-Aid for General Scientific Research (A)
    • 资助金额:
      $15.42万
    • 财政年份:
      1986
    • 负责人:
      KANNO Tomio
    • 依托单位:
    海外基金