The effect of volatile anesthetics on the physico-chemical aspects and the functions of model- and bio-membrane. ---- On the mechanism of anesthesia.

在麻醉挥发性作用的分子位点上，麻醉机制的年度公开会议和由14位从事麻醉作用基础研究的研究者组成的年度闭门会议从几个角度进行了集中讨论。讨论的具体主题是：对膜的作用机理的研究，对膜相界电荷和水合作用的变化的研究，以及对膜和膜界内麻醉剂的压缩和分配的研究。通过这些讨论，我们接近于挥发性麻醉剂与作用部位的结合是非特异性的观点，尽管有报道称存在与麻醉相关的饱和结合位点(Evers，A.S.等。Nature 328,157-160,1987)。在挥发性麻醉剂的非典型Langmuir吸附中可见可饱和结合模式，这是非特异性的。

On the molecular site of volatile anesthetic action, discussions were concentrated from the several points of view in the annual open conference on the mechanism of anesthesia, and in the annual closed shop meeting constituted from 14 investigators who have engaged in the fundamental study on anesthetic action. The concrete themes discussed were those ; on the membrane which is useful for thestudy on the mechanism, on the changes of charge and hydration in the phase boundary of membrane, and on the compression study and partition of ansthetics in the membrane and the membrane boundary.Through these dosciussion, we approached to the common opinion that the binding of volatile anesthetics to action site is of non-specific type, even though the report that there is a saturable binding site related to anesthesia was presented ( Evers,A.S. et al.:Nature 328,157-160,1987 ). Saturable binding mode is seen in atypical Langmuir adsorption of volatile anesthetics which is non-specific.