Photoresponsive and Blood-Compatible Elastomers Composed of poly (oxyeteramethylene) Units

两种官能化聚合物，即，通过四氢呋喃（THF）的活性阳离子聚合或通过使用羟基封端的聚（氧四亚甲基）来合成光响应性和血液相容性弹性体。在四氢呋喃的聚合中，确定了控制分子量的条件，并成功地将二甲氨基引入到聚合物的末端。使聚合物与二卤化物反应以产生紫罗烯型弹性体。研究发现，该弹性体在溶液粘度和气体渗透性方面均具有两亲性。成功地制备了紫精型弹性体，发现其具有光致变色和光机械性，即，光照射改变了材料的颜色，也影响了材料的力学性能.本文合成了一种新的含氧四亚甲基和氧六亚甲基结构的聚脲，研究了它的血液相容性、体外和体内抗凝血试验以及补体系统激活作用.在这三个评价中，聚脲显示出非常好的结果。此外，该聚合物的机械性能在拉伸、应力松弛和动态力学测试中是优异的。聚脲被发现是一种非常有前途的生物医学材料，用于人造器官，例如人造心脏和人造血管。

Two functionalized polymers, i.e., photoresponsive and blood-compatible elastomers were synthesized by means of living cationic polymerization of tetrahydrofuran(THF) or by use of hydroxy-terminated poly(oxytetramethylene). In the polymerization of THF, the conditions governing the molecular weight were established, and it was a success to introduce dimethylamino groups to the ends of the polymer. The polymer was subjected to the reaction with dihalides to produce ionene-type elastomers. The elastomers were found to be amphiphilic both in their solution viscosities and their gas permeabilities. Viologen-type elastomers were successfully prepared, which were found both photochromic and photomecanical, i.e., irradiation of light changed the color and also affeced to the mechanical properties.New polyurethaneurea containing both oxyetramethylene and oxyethylene units was prepared, whose blood copatibilities were investigated; in vitro and in vivo antithrombogenicity tests and the complement system activation. In these three evaluations, the polyurethaneurea displayed very good results. In addition, the mechanical properties of this polymer were excellent in tensile, stress-relaxation, and dynamic mechanical tests. The polyurethaneurea was found to be a very promising biomedical material for artificial organs, for examples, artificial hearts and blood vessels.