Fundamental Studies on the Mechanism of Erythrocyte Aggregation and the Inhibition

各种宏观分子诱导的红细胞聚集速度与剪切速率和温度控制的螺旋桨组合在一起，将其与视频摄像机、图像分析仪和计算机进行了测量。物理化学环境的影响： （1）当pH值增加时，速度增加。碱性碱pH值的聚合物对剪切压力是稳定的。（2）当温度增加时，速度增加。但等离子体中的聚合在15 ° C以下加速。纤维原和IG G的聚合物在形态上有所不同。（3）当体积增加时，速度增加，但减少超过400 mOsm。高分子重量的大分子分子对红细胞聚合有更大的影响，而低分子重量的大分子分子对红细胞聚合有更大的影响。However，有效的融合在分子特性中是不同的。IgG-诱导的细胞聚合被抑制了专辑，在此期间 ... More e纤维原诱导的一个被专辑加速了。以纤维蛋白酶分子为主导的红细胞酶聚合物主要用于重组酶酶链第207-303号<alpha>住院和部分住院在第5章第375-411号<gamma>住院。6.纤维原降解产品的有效性（由塑料制成）对红细胞聚合按顺序进行，纤维原&gt;片段X &gt;片段Y （片段D和E未形成聚合）。关于在红细胞表面上桥接的特定绑定站点的宏分子的证据被发现用于右旋糖酐-和多谷氨酰胺酸诱导的红细胞聚合。Glycoproteins in Addition to the erythrocyte表面对erythrocyte聚合的抑制作用. 8.免疫球蛋白制备和等离子体扩展的效果： （1）免疫球蛋白制备中，酶降解产品的组成，以及与ABO降解产品之间的红细胞的不同相互作用-血葡萄糖和葡萄糖的沉积应被纳入考虑。（2）葡萄糖添加在等离子体扩展器抑制了红细胞聚合。Less（低）

The velocity of erythrocyte aggregation induced by various macromolecules was measured with a shear rate- and temperature-controlled rheoscope combined witha video-camera, an image analyzer and a computer.1. Effect of physicochemical environments: (1) With increasing pH, the velocity increased. The aggregates at alkaline pH were stable for shear stress. (2) With increasing temperature, the velocity increased. But the aggregation in plasma was accelerated below 15゜C. The aggregates by fibrinogen and Ig G were morphologically different.(3)With increasing osmolarity, the velocity increased, but decreased above 400 mOsm.2. High molecular weight macromolecules were more effective for the erythrocyte aggregation than low molecular weight macromolecules were more effective for the erythrocyte aggregation than low molecular weight macromolecules. However, the effective concentration was different among the molecular species.3. Ig G-induced erythrocyte aggregation was inhibited by albumin, whil … More e fibrinogeninduced one was accelerated by albumin.4. The erythrocyte-binding site in fibrinogen molecule for leading to erythrocyte aggregates was deduced to be mainly in residue No. 207-303 of A<alpha> chain and partly in residue No. 375-411 of <gamma> chain.5. The effectiveness of fibrinogen degradation products (by plasmin) for the erythrocyte aggregation was in the order, fibrinogen > fragment X > fragment Y (fragments D and E did not form aggregates).6. An evidence for the specific binding site of bridging macromolecules on the erythrocyte surface was obtained for dextran- and polyglutamic acid-induced erythrocyte aggregation.7. Glycoproteins in addition to sialic acid on the erythrocyte surface were inhibitory for the erythrocyte aggregation.8. Effect of immunoglobulin preparations and plasma expanders: (1) In immunoglobulin preparations, the composition of enzymatic degradation products, the different interaction of erythrocytes with degradation products among ABO-blood grups and the contamination of agglutinins should be taken into consideration. (2) Glucose added in plasma expanders inhibits the erythrocyte aggregation. Less