Life Function and the Most Advanced Organic Chemistry

(1)具有新结构的生物活性化合物-从海绵和章鱼中分离出几种具有生物活性的天然产物。合成了环状核苷、(-)-灯盏花碱、烟曲霉素B、异卡巴环素及其类似物，旨在开发具有更高生物活性的新物质。合成了一种花生四烯酸的氟衍生物，并对其生物转化进行了研究。合成了用于光亲和层析和亲和层析的配体。还研究了引起突变的DNA的化学修饰。(2)生物活性分子合成新方法的开发-开发了多肽合成和大环内酯类合成的去保护新方法。为了合成C-核苷，发明了一种新的双嗜性细胞。对维生素D及其相关化合物的合成进行了研究。手性碱、金属络合物催化剂、不对称去质子法和不对称Aldol反应已被应用于天然产物的合成。合成了多环芳香化合物和冠醚对苯二酚，并对它们的功能进行了研究。手性合成子是在对称化-不对称化概念的基础上，通过对称双酯的酶促水解而产生的。

(1) Bioactive compounds with novel structures- Several bioactive natural products have been isolated from marine sponges and octocoral. Cyclonucleosides, (-)-bulgecinine, fumitremergin B, isocarbacyclin and their analogues have synthesized, aiming at new substances with improved bioactivities. A fluoro derivatives of arachidonic acid have been synthesized and its biotransformation was studied. Syntheses of useful ligands for photoaffinity laveling and affinity chromatography of receptors have been examined. Also studied was the chemical modification of DNA which causes mutation.(2) Development of new synthetic methodologies for bioactive molecules - New methods for the deprotection for peptide synthesis and macrolide synthesis have been developed. A new dienophil was invented for C-nucleoside synthesis. Synthesis of vitamine D and related compounds have been studied. Chiral bases, metal complex catalysts, useful methods for asymmetric deprotonation and asymmetric aldol reaction have been applied for natural product synthesis. Polycyclic aromatic compounds and crowned p-benzoquinones have been synthesized and their functions have been investigated. Chiral synthons have been created by enzymatic hydrolysis of symmetric diesters based on the symmetrization-asymmetrization concept.