Studies on the effect of gastro-intestinal, pancreatic and cardiac hormones on the efferent nerve activity of the autonomic nerve.

在麻醉状态下(乌拉坦500-800 mg/kg和氯醛糖40-70 mg/kg)，静脉注射。本实验观察了五肽胃泌素、CCK-8、生长抑素和心钠素对大鼠自主神经传出活动的影响。注射五肽胃泌素可增强迷走神经胃支的活动，注射CCK-8可增强迷走神经胰支的活动，而应用生长抑素或心钠素可使迷走神经胃支、肝支和胰支的活动减弱。ANP对肾上腺和肾交感神经传出活动也有抑制作用。这些物质的最小有效剂量为100pg。在去脑制剂中，给药后传出活动没有变化。结果表明，五肽胃泌素、CCK-8、生长抑素和心钠素等神经肽释放到静脉循环中，通过血脑屏障不足的下丘脑神经元网络调节自主神经流出。

Under anaesthesia (urethane 500-800 mg/kg and chloralose 40-70mg/kg), effect of i.v. administration of pentagastrin, CCK-8, somatostatin and ANP on efferent activity of autonomic nerve was observed in rats.An increase in activity was observed in gastric branch of vagus nerve following injection of pentagastrin, and that in pancreatic branch of vagus nerve after injection of CCK-8.A decrease in activity was observed in gastric, hepatic and pancreatic branch of vagus nerve following application of somatostation or ANP. ANP application also caused a suppression on activity of adrenal and renal sympathetic efferents. The smallest effective dose of these substances was 100pg.In decerebrated preparations no change in efferent activity was observed after administrations of these substances.The results indicate that neuropeptides such as pentagastrin, CCK-8, somatostatin and ANP released into venous circulation modulate autonomic outflows through hypothalamic neuronal networks surrounding with insufficient blood-brain barrier.