Intracellular signaling in platelets and the role of platelet lipid metabolism and secretome in platelet-mediated vascular, valvular and myocardial thrombo-inflammation

该研究项目旨在确定血小板中的分子信号级联，这些分子信号级联显著参与血小板介导的血管、瓣膜和心肌炎症过程，以及动脉和静脉血栓形成的发展。血小板中血栓炎症的多层过程（细胞内、膜相关和细胞外/分泌）将被更详细地表征，并使用各种体内模型分析其意义。除了血小板中的细胞内信号级联，血小板脂质组（第二信使分子的产生和血小板膜的修饰）和血小板释放的信使物质（脂质，microRNA和趋化因子）的重要性，就其对血小板与炎症细胞的相互作用，特别是对心肌和血管炎症和血栓形成过程的重要性而言，也进行了检查。基于对心血管血栓-炎症过程的更深入了解，将开发预防性干预选择以及新的生物标志物和更有选择性的抗血栓治疗策略，这些策略不影响止血和血管完整性。

This research project aims to identify molecular signal cascades in platelets, which are significantly involved in platelet-mediated processes of vascular, valvular and myocardial inflammation, as well as in the development of arterial and venous thrombosis. The multi-layered processes of thrombo-inflammation in platelets (intracellular, membrane-related and extracellular/secretory) are to be characterized in more detail and their significance analyzed using various in vivo models. In addition to intracellular signal cascades in platelets, the platelet lipidome (generation of second messenger molecules and modification of the platelet membrane) and the importance of messenger substances released by the platelets (lipids, microRNAs and chemokines) in terms of their importance for the platelet interaction with inflammatory cells and especially for processes of myocardial as well as vascular inflammation and thrombosis are examined. Based on a deeper understanding of the processes of cardiovascular thrombo-inflammation, preventive intervention options, as well as new biomarkers and the development of more selective anti-thrombotic therapy strategies, which leave hemostasis and vascular integrity unaffected, are to be developed.