Chemical Research on Bioactive Aquatic Products

众所周知，软珊瑚是生物活性化合物的丰富来源。我们研究了5种软珊瑚的成分，其中3种采集于冲绳县石垣群岛，另外2种采集于鹿儿岛县波诺津海岸。从冲绳软珊瑚中分离出3个新的小松二萜类化合物和4个已知的小松二萜类化合物。新化合物的数量很少，我们还不能确定它们的绝对结构，但其中两种在20 ppm浓度下表现出很强的鱼毒活性。从鹿儿岛地区的两种Xenia软珊瑚中，发现了许多新的Xenia二萜。特别令人感兴趣的是一系列含有新的三环结构的化合物和在a环上有醚键的化合物，它们被命名为xeniether。对分离得到的化合物进行了生物活性测定，其中1个化合物对铜绿假单胞菌具有抗菌活性，另1个化合物对金属蛋白酶和半胱氨酸蛋白酶具有中等抑制活性。另一种化合物也将用于测定许多微生物等。

Soft corals have been known to be a rich source of biological active compounds. We studied the constituents of five species of soft corals, three of which were collected at Ishigaki Islands (Okinawa prefecture) and the another two species were collected at the seashore of Bonotsu (Kagoshima prefecture). From Okinawan soft corals, three new cembrenoid diterpenoids were isolated along with four known cembrenoids. New compounds were so small amount that we could not yet determined their absolute structures, but two of which showed strong ichthyotoxic activity at 20 ppm concentration.From two Xenia soft corals from the Kagoshima area, many new xenai diterpenoids have been characterized. Of particular interest are a series of compounds which contain a new tricyclic structure and compounds with an ether linkage in A ring for which proposed the name xeniaether.Biological activity was tested for some ones among the isolated compounds, in which one-showed antibacterial activity against Pseudomonas aerugins and the other one showed moderate inhibitory activities against metallo-protease and cystein-protease. Another compounds will be also assayed against many microorganisms and so on.