The Role of Maternal Antibody and Complement in Protection of Young Mice Against Infection with Trypanosoma Gambiense.

至少有两种途径的抗体传递从高免疫女性进入胎儿循环。一种是妊娠期的胎盘和卵黄囊途径，另一种是出生后的初乳途径。通过胎盘或卵黄囊或初乳途径移动的抗体是IgG分子。通过哺乳高免疫母鼠的初乳，幼鼠血清中凝集素活性迅速升高。幼鼠初体IgG抗体对锥虫有保护作用。因此，初乳IgG抗体是负责清除病原体的主要成分。笔者试图进一步探讨促进宿主免疫保护的机制。在没有补体的等效区域形成的聚集性锥虫团容易被补体解离。补体介导的等价区团块锥虫解离释放了大约50%的先前结合表面抗原。这些抗原能够再次与新的IgG抗体结合。实验表明，补体沉积使免疫复合物中的二价IgG抗体转变为单价IgG抗体。在补体存在的情况下，这种事件对被感染宿主在体内杀灭病原体有很大的好处，因为它允许更多的抗体附着在表面抗原上，随后启动补体活性。补体无论是通过经典途径激活还是通过替代途径激活，都能完成解离功能。

There are at least two routes of antibody transmittance from hyperimmune females into fetal circulation. The one is placental and yolk sac route during pregnancy, the other is colostral route after birth. Antibodies which move through the placenta or yolk sac or colostral route are IgG molecules. By suckling colostra from hyperimmune mother, agglutinin activity in young mouse serum increased rapidly. Young mice with colostral IgG antibody showed protection against trypanosomes. So, colostral IgG antibody is the main component which is responsible for clearance of pathogens. I try to inquire further into the mechanism by which host immune protection is facilitated. Aggregated trypanosome masses formed in equivalence area without complement are readily dissociated by complement.Complement-mediated dissociation of the clumped trypanosomes in the equivalence area released approximately fifty percent of previous bound surface antigens. These antigens are capable of binding again to new IgG antibody. Experiments indicate that complement deposition alters bivalent IgG antibody in the immune complex into a univalent one. Such event in the presence of complement is of great advantage to the infected host in killing pathogens in vivo, as it allows more antibodies to attach to surface antigens and subsequently initiate complement activity. Complement can fulfill the dissociating function whether it is activated by the classical or by the alternative pathway.