PATHOGENESIS OF LUMBAR NERVE ROOTS UNDER CHRONIC COMPRESSION

在几项脊椎研究中，兔子被选中，因为它们更容易获得和饲养。然而，认识到结构上的差异对于正确推断人类状况的结果是至关重要的。为此，我们用光学显微镜、电子显微镜对人和兔的脊神经根进行了比较研究，主要结果如下：(1)人和兔的脊神经根结缔组织结构基本相同。神经外膜在蛛网膜角与硬脑膜连续。外周神经层离开神经，穿过硬脑膜和蛛网膜之间，内侧神经膜继续与神经根鞘连结，神经根鞘可分为两个基本层。外层细胞排列疏松，内层细胞排列规则、紧密。(2)两者之间存在着一定的差异。(1)兔脊神经节更靠近脊髓。(2)兔蛛网膜层和根鞘较薄，蛛网膜绒毛不发达。3)兔蛛网膜下腔变窄，并用聚脂树脂(MercoxCL-2B)对脊髓神经根微血管进行了实验研究。这一结果表明，脊神经根在微血管方面与周围神经根相似，微血管非常丰富和发达。我们找不到帕克报告的分水岭。根据这些观察，脊神经根可能不仅来自微血管系统，还来自脑脊液。

Rabbits have been selected in several spine studies as they are easier to obtain and keep. However,an appreciation of difference in structural is essential for the correct extrapolation of results in the human situation. For the purpose of this, we studied comparison of the human and rabbit spinal nerve root by means of light microscope,electron microscopy.The main results found were as follows; (1) The structure of the connective tissue of spinal nerve roots in the human and rabbits were essentially same. The epineurium became continuous with dura mater in the subarachnoid angle. The outer perineural layers left the nerve and passed away from it between the dura and arachnoid and the inner layers of perineurium continued with the nerve root sheeth.The nerve root sheeth could be divided into two basic layers. The cells in the outer layers were arranged loosely and in the inner layers were regularly arranged and close to each other. (2) However,there were a few difference between them. i) Spinal ganglion of rabbits were closer to spinal cord. ii) In rabbits,arachnoid and root sheeth were thinner and arachnoid villi were underdeveloped. iii) Subarachnoid space of rabbits was narrower.And,we also did experimental study to observe microvasculature in spinal nerve roots using polyester resin (MercoxCL-2B). This result showed the spinal nerve root is similar to peripheral nerve root in microvasculature which is very abundant and developed. We could not find out water shed which Parke reported. From these observation, there is possibility that spinal nerve roots derived nutrients not only from the microvascular system but also from cerebrospinal fluid.