Proton NMR Studies on Saliva

健康人腮腺唾液的质子核磁共振光谱无论年龄、性别和采集时间如何，都呈现出相似的光谱特征，尽管总强度显示出明显的昼夜节律。另一方面，患者的唾液呈现出明显不同的光谱模式，这可能是由特定疾病引起的。这说明唾液核磁共振可以检测分泌机制对腺体代谢或生理变化的影响。该技术的主要优点是可以在没有任何预处理的情况下进行测量，并且需要相对较短的测量时间（小于30分钟）和少量的样品（0.4ml）。因此，这些初步的研究表明，无菌收集唾液的高分辨率质子核磁共振应该是实用的诊断目的。

Proton NMR spectra of healthy human parotid saliva present similar spectral features regardless of age, sex, and collection time although total intensities show significant circadian rhythms. On the other hand, saliva of patients presented notably different spectral patterns which might result from specific disease. This suggests that NMR of saliva could detect change of secretory mechanism on the gland metabolism or physiological change. The major advantages of this technique would be that measurements can be performed without any pretreatments, and that it requires relatively short measurement times (less than 30 min.) and small amount of samples (0.4ml). Thus these preliminary studies suggest that high resolution proton NMR of aseptically collected saliva should be practially useful for diagnostic purposes.