Development of Surgical Absorbable Implants Using Poly (lactic-acid

聚乳酸、聚乙交酯及其共聚物是一种在生物组织中逐渐吸收的安全的合成聚合物。每种材料的吸收速率都是材料特性因素如：分子量、组成、结晶度的函数。因此，吸收速率可以根据临床目标进行控制。使用这些材料，我们已经开发了以下多种类型的外科材料：用于药物输送系统的基质、外科缝合线、用于缝合加固的质地、支撑垫、止血器、软组织缺损处的补片垫片、防粘连片材、骨连接钉、用于胸部畸形的支柱。动物体内植入试验表明其临床安全性和适用性。阿霉素聚(L-乳酸)微球已应用于临床，其治疗肺癌胸腔积液的有效性发表在《肺癌胸腔积液》杂志(5.1990卷)上。乳酸和己内酯聚合物制成的单丝缝线已被开发出来。与传统的可吸收缝线相比，这种缝线在体内的吸收速度要慢得多。由聚乙交酯制成的支架、垫子和缝线加固现在得到了广泛的应用，其临床可用性和良好的疗效发表在《胸科心血管外科医生》杂志(38.1990卷)上。

Polylactide, polyglycolide and their copolymers are the synthetic polymers which are absorbed in the living tissue gradually with safe. The rate of absorption of each materials were detected to be the function of the factors of the materials characteristics such as : molecular weight, composition, crystallinity. Therefore the absorption rate are able to be controlled according to the clinical objections. Using these materials we have developed many types of surgical materials as following ; matrices for the drug delivery systems, surgical sutures, pledgets for suture reinforcement, bolster, hemostat, patch seat for soft tissue defects, anti-adhesion sheets, bone connective pins, struts for chest deformity. The in vivo implantation tests using animals showed their clinical security and applicability. Some of them have been now used clinically.Adriamycin-Containing poly (L-Lactic Acid) Microspheres have been used clinically and their effectiveness for pleural effusion caused by the lung cancer was reported on the journal of DDS (vol. 5.1990).Monofilament suture made from polymer of lactic acid and caprolactone have been developed. This suture is absorbed in the body more slowly than the conventional absorbable sutures which supposed to be available for vascular surgery.Pledgets, bolster and suture reinforcement made from Polyglycolide are now widely used and their clinical availability and excellent effectiveness were reported on the journal of the Thoracic Cardiovascular Surgeon (vol. 38.1990).