Efficacy of Kanpo Therapy in Ulcerative Colitis

溃疡性结肠炎(UC)被认为存在免疫异常，主要用水杨基-偶氮磺胺吡啶(SASP)和皮质类固醇激素(CS)治疗。观察中药赛瑞托对UC患者化学发光反应(CL)和T淋巴细胞培养功能的免疫缺陷的改善作用。1例活动期UC患者经赛瑞托联合CS或SASP治疗后均得到改善。UC组CL活性较健康对照组明显升高。与对照组相比，活动期UC患者外周血中培养的T细胞系表达更多的CD3抗体，表达更多的CD3抗体。塞热头在体外能有效抑制细胞增殖反应。UC患者已建立的T细胞系产生的肿瘤坏死因子高于正常粘膜T细胞系。Saireito液也能抑制肿瘤坏死因子的产生，与糖皮质激素作用相似。Saireito能抑制中性粒细胞的CL活性。对T淋巴细胞功能的研究提示赛乐托对免疫功能有一定的影响。根据这些结果，我们认为Saireito治疗UC不仅可以减少CS或SASP的剂量，而且可以改善UC的免疫缺陷。

Ulcerative colitis (UC) is supposed to have the immunological abnormalities and is treated mainly with salicyl-azosulfapyridine (SASP) and corricosteroid hormone (CS). We investigated the effect of Saireito (Chinese traditional medicine) on improving the immunological deficiency of the chemiluminescent response (CL) and cultured T lymphocyte function derived from UC patient.One third patient with active UC stage were improved by Saireito therapy combined with CS or SASP. The activity of CL was increased in UC group compared with healthy control group. The CL activities were decreased after p. o. administration of Saireito.The cultured T cell line derived from active UC patients were expressed CD4 positive marker and more responded CD3 antibody compared with control group. Saireitou was efficient to suppress the proliferative response in vitro. The production of TNF in established T cell line from UC patient was higher than the cell line from normal mucosa. The production of TNF was also suppressed by Saireito solution similar to corticosteroid effect.Saireito suppressed the CL activities of neutrophils after p. o. administration. The study on T cell lymmphocyte function suggested the possibility that Saireito has some influence on immune function. On the basis of these results, we suggest that Saireito might be able to use treatment of UC not only for reducing the dose of CS or SASP but improving the immune deficiency of UC.