Co-operative Research on Boron-neutron capture therapy for various Malignant tumors

自1968年以来，Hatanaka及其合作者在日本武藏工业大学、京都大学反应堆和日本原子能研究所的日本反应堆2号（JRR-2）的反应堆中利用巯基十一氢十二硼酸盐（BSH）应用硼中子捕获疗法（BNCT）治疗了146例以上的脑肿瘤患者。自1991年以来，京都大学的Oda（9起案件）和德岛大学的Nakagawa（7起案件）也在KUR审判BNCT。三岛（科比大学）也在12名皮肤黑色素瘤患者身上进行了试验。在神经外科中成为难题的脑干肿瘤和颅底肿瘤正在借助重水和多射野照射进行治疗。Hatanaka也证明了BNCT对巨大脑动静脉畸形（AVM）有良好的疗效，对于肝癌和腹腔脏器癌，肿瘤特异性抗原抗体被认为是硼-10的良好载体（Yanagie，Takahashi，Tokyo University），动物实验也取得了令人鼓舞的结果。东京大学的兽医外科医生Takeuchi和Kadosawa已经通过使用在肿瘤组织中具有令人满意的积累的卟啉的硼化衍生物（BTPP）来研究骨癌。BNCT似乎是一个很好的设备，以治疗困难的病变，在大脑和其他器官，无视先进的现代治疗手段。

Boron neutron capture therapy (BNCT) in Japan has been applied to treating more than 146 brain tumor patients since 1968 by Hatanaka and collaborators utilizing mercaptoundecaphydrododecaborate (BSH) at reactors of Musashi Institute of Technology, Kyoto University Reactor (KUR) and Japan Reactor-2 of Japan Atomic Energy Research Institute (JRR-2). BNCT is now being tried also by Oda of Kyoto University (9 cases) and by Nakagawa of Tokushima University (7 cases) at KUR since 1991. It has been also tried by Mishima (Kobe University) on 12 skin melanoma patients.Brain-stem tumors and skull base tumors, which have posed difficult problems in neurosurgery are being treated with the aid of heavy water and multiportal irradiation. Hatanaka has been also proving good effect ob BNCT upon giant cerebral arteriovenous malformation (AVM).For cancer of liver and abdominal viscerae, antibody to the tumor specific antigen has been considered a good carrier of boron-10 (Yanagie, Takahashi, Tokyo University).An encouraging result was obtained in animal experiment. Bone cancer have been studied by veterinary surgeons Takeuchi and Kadosawa at Tokyo University by using boronated derivative of porphyrins (BTPP) with satisfactory accumulation in the tumor tissue. BNCT appears to be a good device to treat difficult lesions in the brain and other organs which defy sophisticated modern therapeutic means.