Selective segmental sclerotherapy of the liver cancer : Experimental and clinical study

经门静脉注射无水乙醇节段性消融术，即选择性节段性放射治疗(SSS)，被用于治疗肝脏恶性肿瘤。观察SSS对大鼠的治疗效果和安全性。注射乙醇后即刻肝段呈黄白色，轮廓清晰，注射后2~3周完全坏死。中国墨汁的研究结果表明，SS相关的组织坏死可归因于乙醇的直接作用。仅外周血中乙醇浓度略有升高，其他脏器未见组织学改变，对肝肾功能指标也有轻微影响。结论：SSS可在临床上用于治疗肝脏恶性肿瘤。对8例肝细胞癌患者行SSS治疗，CT和血管造影显示肿瘤体积缩小，临床病程明显延长。

Segmental ablation of the liver by transportal ethanol injection, Selective Segmental Screlotherapy (SSS), were developed as the treatment of the malignant hepatic tumor. Therapeutic efficacy and safety of SSS were investigated in rats. The hepatic segments injected with ethanol were observed as a yellowish-white area with distinct outline immediately after injection and showed complete necrosis within 2 to 3 weeks after injection. This findings indicate that necrosis of a targeted hepatic segment can be induced by SSS.The result of investigation with China ink suggest that SSS-associated tissue necrosis is attributable to the direct action of ethanol. Only slight increase in the concentration of ethanol in peripheral blood was observed, and no histological change was found in any other organs, and only slight effect on hepatic and renal function parameters was detected. It is concluded that SSS should be clinically applicable for the treatment of malignant hepatic tumor. Eight patients with hepatocellular carcinoma were performed treatment by SSS.The tumor decreased in size and clinical course was demonstrated by CT and angiographic findings.