Semiconductor Catalyzed Addition Reactions Driven by Visible Light

该项目的目的是开发具有潜在生物活性的精细化学物质的太阳能合成。这将通过半导体粉末催化的不饱和底物之间的可见光驱动的加成反应来实现。加成反应通常是环境友好的过程，因为它们不会产生无用的副产品。正如德国集团实验室最近发现的那样，硫化镉粉末可以光催化亚胺的烯烃加成反应，生成迄今未知的高烯丙基胺。在亚氨基酸酯的情况下，产物是不饱和的a-氨基酸酯，它可以很容易地转化为相应的a-亚氨基酸。根据第一次的机理研究，半导体光催化了施主和受主衬底之间的质子耦合双电子转移。这种非传统的多相光敏化机制在精细化学品的太阳能合成中开辟了广阔的领域。在成功探索这一点之前，必须获得一些基本的机械知识。由于该小组在半导体光催化方面的经验，这项工作将在Erlangen进行。由于伊兹密尔集团已经进行了太阳能化学反应，氨基酸酯的太阳能合成将在那里进行。

Aim of this project is to develop solar syntheses of fine chemicals having potential biological activity. This shall be accomplished through visible light-driven addition reactions between unsaturated substrates catalyzed by semiconductor powders. Addition reactions in generally are environmental friendly processes since they do not produce useless by-products. As recently discovered in the laboratory of the german group, cadmium sulfide powders photocatalyze the addition of olefins to imines affording hitherto unknown homoallyl amines. In the case of an imino ester the product is an unsaturated a-amino acid ester, which can be easily converted into the corresponding a-imino acid. According to the first mechanistic investigations the semiconductor photocatalyzes a proton-coupled double electron transfer between donor and acceptor substrates. This unconventional heterogeneous photosensitization mechanism opens a wide field in solar syntheses of fine chemicals. Before this can be successfully explored, some basic mechanistic knowledge has to be gained. This work shall be performed in Erlangen due to the experience of this group in semiconductor photocatalysis. Since the Izmir group has already conducted solar chemical reactions, the solar synthesis of the amino acid esters will be executed there.