Scintigraphic assessment of bowel absorption based on PET

本研究的目的是建立一种半定量的、方便的测试肠道动态吸收的方法。正电子发射断层扫描（PET）对评估腔内营养物质的吸收非常有帮助，因为在PET上连续拍摄的肝脏图像可以直观地确定门静脉系统吸收的放射性营养物质的量。我们的调查结果概述如下。首先，从时间活性曲线（TAC）可以看出，氨基酸的初始吸收（^<11> c -蛋氨酸）很快被平台期所吸收是相当有效的。最重要的是，TAC可以通过降低氨基酸的特定放射性来控制，因为最初使用高放射性底物的测试无法区分正常志愿者和短肠患者。其次，在氨基酸研究的基础上，采用碳水化合物（^<18> f - fd -半乳糖）。同样，在PET图像上可以清楚地显示半乳糖吸收。其TAC呈非阶段性缓慢上升，与氨基酸明显不同。

Purpose of our study is to establish semi-quantitative a convenient test for measuring dynamic bowel absorption. Positron Emission Tomography (PET) was quite helpful in assessing absorption of intraluminal nutritious staff, because serially taken hepatic images on PET can define visually the amount of radioactive nutrients absorbed via portal venous system. Results of our investigations are outlined as below. First, initial absorption of amino acid (^<11>C-methionine) which is soon bollowed by plateau phase is quite efficient as represented by time activity curve (TAC). Most important is that TAC could be controlled by reducing specific radioactivity of amino acid because original tests using highly radioactive substrate feiled to differentiate normal volunteer from patients with short bowels. Next, carbohydrate (^<18>F-FD-galactose) was used based on the out comes of amino acid study. Likewise, galactose absorption was clearly demonstrated on PET images. Its TAC was non-phasic showed a slow gradual rise, which was distinctly different from that of amino acid.