Development of The Jet Pump for Left and Right Heart Assist.
Development of The Jet Pump for Left and Right Heart Assist.
批准号:
05557063
负责人:
UCHIDA Naoki
金额:
$7.62万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Developmental Scientific Research (B)
财政年份:
1993
资助国家:
日本
项目状态:
已结题
起止时间:
1993 至 1995
中文摘要
我们开发了微型喷射泵作为心脏辅助装置。喷射泵由喷嘴、进水口、喉部和导流管依次组成,所有部件均为同轴锥形或柱状管状,泵内无运动部件。为了得到两种环境下的数据,我们制作了两种类型的模型。黄铜制成的泵为试验型,用于台架试验,另一种为丙烯酸酯树脂和乙烯基铬内酯制成的动物实验型。在台架试验中,采用40%甘油溶液,在喷射量为1010ml/min的情况下,泵的输出功率为3070ml/min,后负荷为40 mm Hg。我们用光纤激光测速仪测量了血流速度,最大射流速度在10m/s以内,这是以前报道的机械性血液溶解的相对非常安全的区域。当自然心脏处于左心转流辅助下的室颤状态时,右心系统射流量为1.8或2.0 L/min时,左心输出量增加2.5 L/min。综上所述,尽管射流泵在临床应用中仍存在溶血、定位、泵效等问题,但仍有望成为右心辅助治疗的有用装置。微射流泵在左心辅助和儿童辅助心脏中的应用值得进一步研究。
英文摘要
We have developed the micro jet pump as a heart assist device. Jet pump was consisted in order NOZZLE,INLET,THROAT and DIFFUSER.All compornents were fabricated to cone or column pipe on the same axis and there was no moving parts in this pump. We made 2 types of models in order to get the datum in 2 enviroment. One made from brass was the type for bench test to examine the caracteristics of the pump, and another made from acril resin and vinylchrolide was the type for animal experiment.In the bench test, we got 3070 ml/min of pump output by 1010 ml/min of jet flow volume against 40 mmHg afterload using 40% glycerine solusion. We measured flow velosity by Fiberoptic Laser Velocimeter, and maximum jet flow velosity was within 10 m/sec which was reported previously as the comparativery safe zone for machanical hemokysis.We performed animal experiments using adult goat. When natural heart was the condition of ventricular fiblilation under the assist of left heart bypass, 1.8 or 2.0 l/min of jet flow in right heart system made 2.5 l/min of increase of left heart output.In conclusion, although there remain many probrems for clinical usage of jet pump, including heamolysis, positioning and pump efficiency, we hope it would be useful device for right heart assist. And the use of micro jet pump for left heart assist and child heart assist should be study in the future.
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会议论文
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批准号:23740328
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资助金额:$1.75万
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财政年份:2011
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负责人:UCHIDA Naoki
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依托单位:
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依托单位:
Effects of endothelial cell growth factor on endotheliazation of small diameter vascular graft
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批准号:05671106
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1993
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负责人:UCHIDA Naoki
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依托单位:
海外基金