YhcB, a crucial player in the control of bacterial cell envelope biogenesis

所有的生命都依赖于一个细胞膜来包裹使生命成为可能的化学反应。但是细胞膜是如何生长的呢？如何在合适的时间、适量地将细胞膜的每个成分结合到细胞膜中，以防止细胞死亡，一直是细菌学中的一个长期问题。使用高通量遗传筛选和生化方法的独特组合，该项目将表征革兰氏阴性细菌细胞膜生长的关键调节因子。这项研究产生的知识将提供对细菌中一个基本过程的洞察，将开发新的技术来探索蛋白质相互作用，并将提供解决植物、人类和动物感染的新途径。

All life depends on a cell envelope to enclose the chemical reactions that make life possible. But how do cell envelopes grow? How each component of the cell envelope is incorporated into the envelope at the right amount and in the right time to prevent cell death, has been a longstanding question in bacteriology. Using a unique combination of high through put genetic screens and biochemical approaches, this project will characterise a key regulator of cell envelope growth in Gram-negative bacteria. Knowledge arising from this research will provide insight into a fundamental process in bacteria, will develop new technology to probe protein interactions, and will provide novel avenues to solve infection in plants, humans and animals.