Regulation of cell function by ion channels.

赤池急性分离中枢神经元，并进行全细胞电压钳。实验动物对n -甲基- d -天冬氨酸的反应随着年龄的增长而下降，这种下降是由于受体分布密度的降低。井上发现，K +离子从神经轴突膜和雪旺细胞之间的空间被主动移除。Ohmori检查了新生大鼠MNTB内的突触传递，发现传递在出生后第4天建立，Ca^<2+>电流的增加是突触传递发展的基础。Okada研究了体积敏感的cl -通道在细胞体积调节中的作用，并讨论了上皮细胞分泌与cl -通道的关系。Kameyama检查了维持Ca^<2+>通道活性的细胞内因子，并指出该因子依赖于一些未知的蛋白质和细胞内更多的ATP。Kitasato检查了胰腺B细胞膜电位变化的自发节律，并阐明了细胞内ATP浓度的变化和A细胞释放胰高血糖素的过程。Kuba记录了神经末梢细胞质Ca^<2+>浓度的变化，认为Ca^<2+>-诱导的Ca^<2+>释放与递质释放有关。Kurachi成功克隆了一个新的SUR亚型，并指出这个新的亚型与平滑肌中ATP敏感的K通道有关。铃木研究了胃平滑肌中的拉伸激活通道。Seyama提出了细胞内Mg使l型Ca^<2+>通道失活的假设，并提供了一些实验证据来支持这一假设。Takahashi研究了bFGF在被囊胚胎神经诱导中的作用，提出bFGF在神经诱导中是一个普遍存在的因子。Tonosaki制备了一种针对视网膜细胞的单克隆抗体，并研究了目标蛋白在感觉信号转导中的作用。堀江研究了血管紧张素II对心肌细胞的影响。Yamagishi检查了神经节细胞中cl通道的特性。Noma测量单个心肌细胞的细胞体积，表明camp调控的cl -通道参与细胞体积调节。少

Akaike acutely dissociated central neurons and performed the whole cell voltage clamp. It was found that the response to N-methyl-D-aspartate was decreased with age of the experimental animal, and this decrease was attributed to a decrease in the distribution density of the receptor. Inoue found that the K^+ ions are actively removed from the space between the nerve axonal membrane and the Schwann cells. Ohmori examined the synaptic transmission within MNTB in the newborn rat and showed that the transmission is established at postnatal day 4 and the increase in the Ca^<2+> current underlies the development of the synaptic transmission. Okada examined the role of the volume-sensitive Cl-channel in the cell-volume regulation, and discussed the relationship between the secretion of the epithelial cells and the Cl-channel. Kameyama examined the intracellular factor, which maintains the activity of the Ca^<2+> channel, and indicated that this factor is dependent on some unknown protein and … More ATP within the cell. Kitasato examined the spontaneous rhythm in the membrane potential change in the B cell in the pancreas, and clarified that changes in intracellular concentration of ATP,and the release of glucagon from A cells are involved. Kuba recorded the changes in the cytoplasmic Ca^<2+> concentration in the nerve terminal and suggested that the Ca^<2+>-induced Ca^<2+> release is responsible for the transmitter release. Kurachi succeeded in cloning a new SUR subtype and indicated that this new subtype is responsible for the ATP sensitive K channel in the smooth muscle. Suzuki investigated the stretch-activated channel in the gastic smooth muscle. Seyama proposed a hypothesis that the intracellular Mg inactivates the L-type Ca^<2+> channel and provided several experimental evidence to support the hypothesis. Takahashi investigated the role of bFGF in the neural induction in the Tunicate embryo, and proposed that bFGF is an ubiquitous factor in the neural induction. Tonosaki prepared a monoclonal antibody for the retinal cells and investigated the role of the target proteins in the sensory signal transduction. Horie investigated the effect of angiotensin II on the cardiac myocytes. Yamagishi examined the properties of the Cl-channels in the ganglion cells. Noma measured the cell volume of single cardiac myocytes and indicated that the cAMP-regulated Cl-channels are involved in the cell volume regulation. Less