Regulation of endometrial function by KGF

为了阐明角化细胞生长因子（keratinocyte growth factor， KGF）在调节人子宫内膜功能和着床中的作用，我们研究了月经周期和妊娠早期蜕膜中子宫内膜KGF mRNA的变化以及KGF对滋养母细胞的生物学作用。KGF mRNA水平在黄体期和妊娠早期升高，提示其受黄体酮控制。我们还在绒毛膜绒毛和绒毛膜癌细胞中发现了HGF受体mRNA。因此，在蜕膜细胞中产生的KGF以旁分泌方式作用于滋养细胞，KGF在体外增强绒毛膜癌细胞系的hCG分泌，但不影响细胞增殖。这些结果表明KGF在子宫内膜/蜕膜-滋养层相互作用中起重要作用。

In order to clarify a role of keratinocyte growth factor (KGF) in the regulation of human endometrial function and implantation, we investigated the changes in KGF mRNA in endometrium during menstrual cycle and in decidua of early pregnancy as well as the biological effect of KGF on trophsblastic cells.The levels of KGF mRNA increased in luteal phase and in early pregnancy, suggesting that it is under the control of progesterone. We also demonstrated the HGF receptor mRNA in chorionic villi and choriocarcinoma cells. Thus, KGF produced in decidual cells acts on trophoblasts in a paracrine fashion, KGF enhanced hCG secretion from choriocarcinoma cell line in vitro, but not influence cell proliferation.These results indicate that KGF plays an important role in endometrial/decidual-trophoblastic interaction.