Application of anti-washout type fast-setting calcium phosphate cement for the reconstruction of jaw bone

通过骨组织反应评价抗冲刷型快凝磷酸钙骨水泥（aw-FSCPC）在口腔颌面外科、整形外科和重建外科临床应用的可行性。因此，在这项研究中，aw-FSCPC植入到实验动物的骨缺损中，并使用常规CPC（c-CPC）作为对照材料，对其组织反应进行组织病理学检查。aw-FSCPC对骨组织的组织反应与c-CPC相似，术后2周骨髓内新骨沿着骨水泥形成，骨水泥与新骨之间无纤维软组织介入。随着植入时间的延长，新骨的数量增加。骨水泥与软组织界面处，c-CPC颗粒分散在皮肤组织中，周围可见大量异物巨细胞;而aw-FSCPC周围纤维组织较薄，炎症反应轻微，异物巨细胞较少。也就是说，aw-FSCPC对软组织表现出优异的组织反应。我们得出结论，aw-FSCPC具有良好的潜在价值，在口腔颌面，整形和重建外科的更广泛的临床应用，因为它显示出更快的设置和更高的机械强度，在这些外科手术所需的早期，以及良好的骨传导性和良好的生物相容性。

Anti-washout-type fast-setting calcium phosphate cement (aw-FSCPC) was evaluated in terms of bone tissue response to investigate its feasibility for its clinical use in oral and maxillofacial, plastic, and reconstructive surgery. In this investigation, therefore, aw-FSCPC was implanted into bone defects made in experimental animals, and its tissue response was examined histopathologically using conventional CPC (c-CPC) as control materials. aw-FSCPC showed excellent tissue response toward bone tissues similar to c-CPC.New bone, like a bridge, was formed along the cement in the bone marrow and no fibrous soft tissue intervened between the cement and new bone 2 weeks after surgery. The amount of new bone was increased with implantation time. At the interface between cement and soft tissue, small particles of c-CPC had been scattered in the cutaneous tissue and many foreign-body giant cells were collected around the scattered c-CPC.In contrast, aw-FSCPC was surrounded by thin fibrous tissue with slight inflammatory response and few foreign-body giant cell was observed. Namely, aw-FSCPC showed excellent tissue response toward soft tissues. We conclude that aw-FSCPC have good potential value for its use in wider clinical applications in oral and maxillofacial, plastic and reconstructive surgery, since it shows faster setting and higher mechanical strength in the early period that are required in these surgical procedures as well as good osteoconductivity and excellent biocompatibility.