Study on oncoimmunology in carrier children of HTLV-I

我们对人类T淋巴细胞病毒I型(HTLV-I)的母婴传播进行了12年的调查。结果表明：1)HTLV-I母婴传播率，奶粉为4.9%，母乳为8.0%。在母乳喂养者中，母乳喂养7个月以上的儿童的传播率高于母乳喂养6个月以下的儿童(25.0%比2.5%)。母婴传播率差异有统计学意义。2)出生后6个月左右检出的母亲传播的抗HTLV-I抗体可用于抵御HTLV-I垂直感染。3)HTLV-I传播组儿童血清可溶性白介素2受体水平高于HTLV-I携带者母亲所生非传播组和正常对照组。但两组之间没有显著差异，因为在这些组中接受测试的儿童数量很少。4)需要进一步的研究，如针对HTLV-I携带者母亲所生儿童的人类白细胞抗原(HLA)和针对HTLV-I感染的免疫学研究。

We have investigated the transmission of human T-lymphotropic virus type I (HTLV-I) from mother-to-child for 12 years. The results are follows :1)Transmission of HTLV-I from mother-to-child occurred with the rate of 4.9% in bottle feeders, and 8.0% in breast feeders. Among breast feeders, the rate of transmission was higher in the group of more than 7 months breast-fed children than in the group of less than 6 months brestfed children (25.0% vs 2.5%). There was statistically significant differences in the rate of trans-mission between the two groups.2)Anti-HTLV-I antibody transmitted from mother, which have been detected by about 6 months after birth, was suggested to act as defensive against HTLV-I vertical infection.3)The level of soluble interleukin-2 receptor was higher in the group of HTLV-I transmitted children than that in the group of non-transmitted children born to HTLV-I carrier mothers, and that in the group of normal control children. But no significant differences was admitted between the groups, due to small numbers of children tested in those groups.4)Further investigations such as immunological studies against HTLV-I infection and human leukocyte antigens (HLA) among children born to HTLV-I carrier mothers are needed.