Morphological and functional study of endothelium in implanted free graft

带蒂胸内动脉（ITA）由于其良好的长期通畅性，已成为缺血性心脏病（IHD）冠状动脉旁路移植术（CABG）的首选移植物导管。然而，在大多数情况下，冠状动脉搭桥需要多次冠状动脉重建术，因此，我们在体内研究了杂种狗游离动、静脉移植物的形态和功能，并在临床上研究了动、静脉移植物的通畅程度和冠状动脉搭桥后的后期效果。1995年研究了杂种狗自体游离股动脉静脉移植早期形态学和功能的变化。静脉移植物（VG）的内皮在移植后脱落并再生至移植后3周，而动脉移植物（AG）无明显变化。在功能上，VG在移植后早期任何阶段的前列环素产量都低于AG。1996年对平均移植9.8个月的杂种犬进行了后期形态学和功能变化的研究。晚期AG全部通畅，静脉移植物通畅率为70%。形态学上，AG中内皮细胞保存完好，而VG中内皮细胞很少有血小板样物质粘附。在功能上，VG中前列环素的产生量在后期低于AG。1995年和1996年，270例隐静脉移植物和28例AG作为游离移植物，206例AG作为原位移植物CABG。术后早期各移植物的通畅程度相似，但在随访后期，多动脉导管患者术后心脏死亡无发生率和心脏事件无发生率均优于SVG患者。在我们的实验研究中，AG植入后的形态和功能优势似乎是CABG术后后期临床效果良好的部分原因。少

Use of the pedicled internal thoracic artery (ITA) has become well established as a first choice of graft conduit for coronary artery bypass grafting (CABG) in ischemic heart disease (IHD) because of the good long-term patency of the graft. However, in most cases, multiple coronary revascularization are required for CABG and thus, morphology and function of free arterial and vein graft of mongrel are studies in vivo and also graft patency of arterial and vein graft and late result after CABG are clinically studied.In 1995 early morphological and functional changes were studied in autologous free femoral arterial and vein graft of mongrel. The endothelium of the vein graft (VG) detached after implantation and regenerated until 3 weeks after implantation, while no significant changes occurred in the arterial graft (AG). In function, the production of prostacylin of VG was lower than that of AG in any early phase after transplantation.In 1996 the late morphological and functional changes … More were studied in the mongrel which had been received graft implantation for an average of 9.8 months. In late period, the AG was patent in all, while the patency rate of the vein graft was 70%. Morphologically the endothelial cell in AG was well preserved, while the endothelial cell was rarely detected with an adhesion of platelet-like materials in the VG.Functionally the production of prostacyclin of prostacyclin was lower in VG than that of AG in late period.In 1995 and 1996,270 saphenous vein grafts and 28 AG were used as free grafts and 206 AG were used as in situ graft CABG.Early postoperative patency of the graft was similar in each graft, however, in late follow-up period, postoperative cardiac death free rate and cardiac event free rate were better in patients with multiple arterial conduit than those with SVG.The morphological and functional superiority of the AG after implantation seen in our experimental studies seemed contribute in a part to the good clinical results in late periods after CABG. Less