Studies on the microcirculation of the macula and optic nerve head related to the visual function in eyes with diabetes mellitus

1.该方法具有良好的准确性和重复性，并在1996年第12届国际眼科研究大会（日本横滨）上发表。视神经乳头边缘血流速度随年龄增长而变化，6龄组明显高于4、8龄组。视神经头颞下缘的运动速度明显低于颞上缘。这些结果为研究糖尿病眼的循环变化提供了良好的对照，并可能提示循环功能不全对青光眼的影响。这些结果将在1997年日本青光眼学会会议上报告。无糖尿病视神经病变眼（d组）视神经乳头边缘血流速度与正常眼相比无明显变化。糖尿病性视神经病变（c组）7只眼，其中5只眼表现为缺血性视神经炎，2只眼为视乳头水肿。c组血流速度较d组及正常组减慢。在随访期间，视觉功能没有退化。提示视乳头循环功能不全与视功能障碍有密切关系.激光散斑流图的测量区域仍然很窄。在黄斑血流速度的测量上，我们不能保证对每一个有视觉功能障碍的患者都进行了相同的测量。因此，我们放弃使用现有的仪器测量黄斑血流速度。我们正在计划建立下一个版本的激光散斑流图，它具有更宽的测量区域，并可以在测量过程中监视测量位置。

1. The good accuracy and reproducibility were made sure and those results were reported at the 12th International Congress of Eye Research, 1996 (Yokohama, Japan).2. The blood velocity of the rims of optic nerve heads changed by aging, the velocity at the 6th decade was significantly higher than that at 4th and 8th decades. The velocity at the inferotemporal rims was significantly lower than that at the superotemporal rims of the optic nerve heads. Those results were good control for studying on the circulatory changes in eyes with diabetes mellitus, and might indicate that the circulatory insufficiency influenced to the glaucoma. Those results will be reported on the Japanese Glaucoma Society Meeting, 1997. The blood velocity at the rims of optic nerve heads in eyes without diabetic optic neuropathy (group d) showed no significant change compared with normals. The eyes with diabetic optic neuropathy (group c) were 7 ; 5 of 7 eyes showed ischemic neuritis and 2 of 7 eyes were papilledema. The blood velocity in group c decreased compared with that in the group d and normals. The visual function did not regress through the followed-up periods. Those results indicate that there is a tight relationship between the circulatory insufficiency in optic nerve heads and the visual dysfunction.3. The measured area of the laser speckle flowgraphy is still narrow. On the measurements of macular blood velocity, we can not make sure that we followed same points for each patient with the visual dysfunction. Therefore, we quit to measure the macular blood velocity using the resent instrument. We are making the plan to build up the next version of the laser speckle flowgraphy which have a wider measured area and can monitor the measured site during measurements.