The relationship between the carcinoma of the tongue and the muscle by 3D imageing.

本研究切除了舌缘原发性鳞状细胞癌，将肿瘤与宿主交界处的连续样本可视化为计算机三维重建图像，以研究不同侵袭机制的各种肿瘤的进展形式与进展部位舌内肌方向的关系。肿瘤以三种方式侵入舌肌被膜：间质组织侵入肿瘤肺泡结构，压迫肌肉纤维束（1型），肿瘤扩散性侵入肌肉纤维束的孔隙，有或没有肿瘤形成的索状肺泡结构（2型），肿瘤向肌纤维束的侵犯（3型），呈1型进展方式的肿瘤，其进展方式与舌内肌方向无关。在2型和3型侵袭模式中均观察到1型，这表明侵袭有限的肿瘤倾向于遵循1型进展模式。2型进展型肿瘤不规则地侵犯肌纤维束的孔隙。其中一些进展方向与舌浅肌的进展方向相同。在4C型和4d型侵袭模式中观察到2型，表明具有高侵袭性的肿瘤倾向于遵循2型进展模式。显示3型进展模式的肿瘤表明，由肿瘤细胞和间质组织组成的小肿块与肌纤维束中的肌纤维的进展方向相同。在4D型浸润中观察到3型，这表明与浸润强度有关。切除区域的检查表明，1型肿瘤周围的均匀安全区是必要的。对于2型和3型，在舌肌方向上的更宽的安全区是必要的，因为肿瘤倾向于在该方向上进展。

This study removed primary squamous-cell carcinoma on the lingual margin, and visualized the sequential samples from the border area between the tumor and host as computerized three-dimensional reconstructed images to examine how the progress forms of various tumors with different invasion mechanisms are related to the intrinsic lingual muscle direction at the progress site.The tumors invaded into the lingual muscular tunics in three modes : invasion of the tumor alveolar structure with interstitial tissues, which presses muscular fibrous fascicles (Type 1), diffuse invasion of the tumor into the pores of the muscular fibrous fascicles with or without the funicular, alveolar structure formed by the tumor (Type 2), and the invasion of the tumor into muscular fibrous fascicles (Type 3).The tumors showing the Type 1 progress mode showed no relation between tumor progress form and intrinsic lingual muscle direction. Type 1 was observed in both the type 2 and 3 invasion modes, which indicates that tumors with limited invasion tend to follow the Type 1 progress mode. The tumors showing the Type 2 progress mode irregularly invaded the pores of the muscular fibrous fascicles. Some of them progressed in the same direction as that of the superficial lingual muscle. Type 2 was observed in the type 4C and 4d invasion modes, indicating that tumors with high invasion tend to follow the Type 2 progress mode. Tumors showing the Type 3 progress mode indicated that small masses consisting of the tumor cells and interstitial tissues progressed in the same direction as that of the muscular fibers in the muscular fibrous fascicles. Type 3 was observed in type 4D invasion, which suggests a relation to invasion intensity.An examination of the excision area showed that a uniform safety zone around the tumor would be necessary for Type 1. For Type 2 and 3, a wider safety zone in the direction of the lingual muscle would be necessary because the tumor tends to progress in that direction.