Synthetic Studies on Biologically Active Poly-Functionalized Carbazoles

1. 以吲哚2,3键为关键步骤，采用新型的烯介导电环反应合成了自由基清除剂卡拉抑素和海洋生物碱羟唑。合成了新的四环恶唑[4,5-c]咔唑和恶唑[5,4-c]咔唑环作为抗氧化抗他汀类药物（A_<1-4>和B_<2-5>）和咔唑喹啉类药物（A-F）的功能化前体。基于2,3功能化吲哚烯介导的电环反应，建立了一种新的苯并环化方法，为高功能化咔唑环提供了有效途径，完成了咔唑他汀、羟基唑和咔唑喹啉B到F的全合成。此外，还首次合成了咔唑喹诺素B、C、E和F。

1. The free radical scavenger carazostatin and the marine alkaloid hyellazole have been synthesized by a new type of allene-mediated electrocyclic reaction involving the indole 2,3-bond as a key step.2. New tetracyclic oxazolo [4,5-c] carbazole and oxazolo [5,4-c] carbazole ring systems as functionalized precursors to antioxidative antiostatins (A_<1-4> and B_<2-5>) and carbazoquinocins (A-F) were synthesized.3. A new benzo-annelation method based on the allene-mediated electrocyclic reaction of 2,3-functionalized indoles provides an effective route to the highly-functionalized carbazole ring, and the total syntheses of carazostatin, hyellazole and carbazoquinocins B to F have been completed. Moreover, the first total syntheses of carbazoquinocins B,C,E and F were demonstrated.