Regional cerebral blood flow during self-paced repetitive Iifting tasks with a precision grip

用SPECT和1-123 IMP示踪剂测量了静息、持握和用精确握法自起搏重复举起小物体时的局部血流量（rCBF）。对于提升任务，测试了两种物体重量条件;一种是恒定重量（400 g），另一种是可变重量（200、400和600 g）。在所有条件下，使用眼罩最小化视觉输入。用SPM检测rCBF的增加和减少，并进行统计学分析。有没有显着的rCBF增加或减少，由于持有的对象，而在提升一个恒定的重量，有一个显着的增加，对侧初级运动皮层和初级感觉皮层。对侧辅助运动区也有增加的趋势。此外，在与视觉相关的对侧区域（Brodman区8、37和17）观察到显著的rCBF降低。研究结果表明，这些是主要的和必要的领域，为控制与精确的握举任务。当变重条件下相比，恒定的重量条件下，一个显着的rCBF增加，发现对侧扣带回，对应Brodman的区域24/32。对侧下额前皮质（11区）和同侧枕区（Brodman区2/40）也有显著增加。因此，这些结果表明，这些地区起着重要的作用，在控制快速调整的把握力量的变化，被提升的物体的重量。

Regional Blood flow (rCBF) was measured using a SPECT with 1-123 IMP tracer during resting, holding and self-paced repetitive lifiting of a small object with the precision grip. For the lifting task, two object weight conditions were tested ; one with a constant weight (400g) and the other with variable weights (200,400 and 600g). In all conditions, visual input was minimized using an eyemask. A SPM was used to test the rCBF increase and decrease statistically. There was no significant rCBF increase or decrease due to holding of the object, while during lifting a constant weight, there was a significant increase in the areas of contra lateral primary motor cortex and primary sensory cortex. A tendency of increase was also revealed for the contra lateral supplementary motor area. In addition, a significant rCBF decrease was observed in the contralateral areas related to vision (Brodman's area 8,37, and 17). The findings suggest that these are the primary and essential areas for the control of lifting tasks with the precision grip. When the variable weight condition was compared with the constant weight condition, a significant rCBF increase was found for the contralateral cingulate gyrus which corresponded to Brodman's areas 24/32. There was also significant increase in the contra lateral inferior prefronal cortex (area 11) and the ispliateral occipital region (Brodman's areas 2/40). The results thus suggest that these areas plays an important role in the control of quickly adjusting the grasp forces to the changes in weight of objects being lifted.